Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers

Maribel Casas; Mark Nieuwenhuijsen; David Martínez; Ferran Ballester; Xavier Basagaña; Mikel Basterrechea; Leda Chatzi; Cécile Chevrier; Merete Eggesbø; Mariana F. Fernandez; Eva Govarts; Mònica Guxens; Joan O. Grimalt; Irva Hertz-Picciotto; Nina Iszatt; Monika Kasper-Sonnenberg; Hannu Kiviranta; Manolis Kogevinas; Lubica Palkovicova; Ulrich Ranft; Greet Schoeters; Evridiki Patelarou; Maria Skaalum Petersen; Maties Torrent; Tomas Trnovec; Damaskini Valvi; Gunnar Vase Toft; Pal Weihe; Nynke Weisglas-Kuperus; Michael Wilhelm; Jürgen Wittsiepe; Martine Vrijheid; Jens Peter Bonde

doi:10.1016/j.envint.2014.09.013

Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers

Maribel Casas, Mark Nieuwenhuijsen, David Martínez, Ferran Ballester, Xavier Basagaña, Mikel Basterrechea, Leda Chatzi, Cécile Chevrier, Merete Eggesbø, Mariana F. Fernandez, Eva Govarts, Mònica Guxens, Joan O. Grimalt, Irva Hertz-Picciotto, Nina Iszatt, Monika Kasper-Sonnenberg, Hannu Kiviranta, Manolis Kogevinas, Lubica Palkovicova, Ulrich RanftGreet Schoeters, Evridiki Patelarou, Maria Skaalum Petersen, Maties Torrent, Tomas Trnovec, Damaskini Valvi, Gunnar Vase Toft, Pal Weihe, Nynke Weisglas-Kuperus, Michael Wilhelm, Jürgen Wittsiepe, Martine Vrijheid, Jens Peter Bonde

Institut for Folkesundhedsvidenskab

65 Citationer (Scopus)

Abstract

Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.

Originalsprog	Engelsk
Tidsskrift	Environment International
Vol/bind	74
Sider (fra-til)	23-31
Antal sider	9
ISSN	0160-4120
DOI	https://doi.org/10.1016/j.envint.2014.09.013
Status	Udgivet - 1 jan. 2015

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10.1016/j.envint.2014.09.013

Citationsformater

Casas, M., Nieuwenhuijsen, M., Martínez, D., Ballester, F., Basagaña, X., Basterrechea, M., Chatzi, L., Chevrier, C., Eggesbø, M., Fernandez, M. F., Govarts, E., Guxens, M., Grimalt, J. O., Hertz-Picciotto, I., Iszatt, N., Kasper-Sonnenberg, M., Kiviranta, H., Kogevinas, M., Palkovicova, L., ... Bonde, J. P. (2015). Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers. Environment International, 74, 23-31. https://doi.org/10.1016/j.envint.2014.09.013

Casas, M, Nieuwenhuijsen, M, Martínez, D, Ballester, F, Basagaña, X, Basterrechea, M, Chatzi, L, Chevrier, C, Eggesbø, M, Fernandez, MF, Govarts, E, Guxens, M, Grimalt, JO, Hertz-Picciotto, I, Iszatt, N, Kasper-Sonnenberg, M, Kiviranta, H, Kogevinas, M, Palkovicova, L, Ranft, U, Schoeters, G, Patelarou, E, Petersen, MS, Torrent, M, Trnovec, T, Valvi, D, Toft, GV, Weihe, P, Weisglas-Kuperus, N, Wilhelm, M, Wittsiepe, J, Vrijheid, M & Bonde, JP 2015, 'Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers', Environment International, bind 74, s. 23-31. https://doi.org/10.1016/j.envint.2014.09.013

@article{73d6d81d7e2f4bd6ae32f1b80fad4ab4,

title = "Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers",

abstract = "Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.",

author = "Maribel Casas and Mark Nieuwenhuijsen and David Mart{\'i}nez and Ferran Ballester and Xavier Basaga{\~n}a and Mikel Basterrechea and Leda Chatzi and C{\'e}cile Chevrier and Merete Eggesb{\o} and Fernandez, {Mariana F.} and Eva Govarts and M{\`o}nica Guxens and Grimalt, {Joan O.} and Irva Hertz-Picciotto and Nina Iszatt and Monika Kasper-Sonnenberg and Hannu Kiviranta and Manolis Kogevinas and Lubica Palkovicova and Ulrich Ranft and Greet Schoeters and Evridiki Patelarou and Petersen, {Maria Skaalum} and Maties Torrent and Tomas Trnovec and Damaskini Valvi and Toft, {Gunnar Vase} and Pal Weihe and Nynke Weisglas-Kuperus and Michael Wilhelm and J{\"u}rgen Wittsiepe and Martine Vrijheid and Bonde, {Jens Peter}",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.envint.2014.09.013",

language = "English",

volume = "74",

pages = "23--31",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

TY - JOUR

T1 - Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs

T2 - exposure-response relationship and effect modifiers

AU - Casas, Maribel

AU - Nieuwenhuijsen, Mark

AU - Martínez, David

AU - Ballester, Ferran

AU - Basagaña, Xavier

AU - Basterrechea, Mikel

AU - Chatzi, Leda

AU - Chevrier, Cécile

AU - Eggesbø, Merete

AU - Fernandez, Mariana F.

AU - Govarts, Eva

AU - Guxens, Mònica

AU - Grimalt, Joan O.

AU - Hertz-Picciotto, Irva

AU - Iszatt, Nina

AU - Kasper-Sonnenberg, Monika

AU - Kiviranta, Hannu

AU - Kogevinas, Manolis

AU - Palkovicova, Lubica

AU - Ranft, Ulrich

AU - Schoeters, Greet

AU - Patelarou, Evridiki

AU - Petersen, Maria Skaalum

AU - Torrent, Maties

AU - Trnovec, Tomas

AU - Valvi, Damaskini

AU - Toft, Gunnar Vase

AU - Weihe, Pal

AU - Weisglas-Kuperus, Nynke

AU - Wilhelm, Michael

AU - Wittsiepe, Jürgen

AU - Vrijheid, Martine

AU - Bonde, Jens Peter

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.

AB - Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.

U2 - 10.1016/j.envint.2014.09.013

DO - 10.1016/j.envint.2014.09.013

M3 - Journal article

C2 - 25314142

SN - 0160-4120

VL - 74

SP - 23

EP - 31

JO - Environment international

JF - Environment international

ER -

Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers

Abstract

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