PNA Technology

TY - JOUR

T1 - PNA Technology

AU - Nielsen, Peter E.

PY - 2004/3

Y1 - 2004/3

N2 - Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

AB - Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

KW - Anti-Bacterial Agents/chemistry

KW - Antisense Elements (Genetics)/chemistry

KW - Antiviral Agents/chemistry

KW - DNA/chemistry

KW - Hydrogen Bonding

KW - Intercalating Agents/chemistry

KW - Peptide Nucleic Acids/analysis

KW - RNA/chemistry

U2 - 10.1385/MB:26:3:233

DO - 10.1385/MB:26:3:233

M3 - Review

C2 - 15004293

SN - 1073-6085

VL - 26

SP - 233

EP - 248

JO - Molecular Biotechnology

JF - Molecular Biotechnology

IS - 3

ER -