Pitfalls and opportunities for epigenomic analyses focused on disease diagnosis, prognosis, and therapy

TY - JOUR

T1 - Pitfalls and opportunities for epigenomic analyses focused on disease diagnosis, prognosis, and therapy

AU - Lauschke, Volker M

AU - Ivanov, Maxim

AU - Ingelman-Sundberg, Magnus

PY - 2017/9

Y1 - 2017/9

N2 - Many studies assess epigenetic signatures in bodily fluids and make conclusions about epigenetic patterns in inaccessible tissues of interest such as brain, thus neglecting the tissue specificity of epigenetic marks. There is a growing lag between the forefront of epigenetics and the methods routinely applied in epigenetic studies. For instance, while techniques to detect the functionally relevant methylcytosine derivate 5-hydroxymethylcytosine were described years ago, only a few studies use such detection methods.

AB - Many studies assess epigenetic signatures in bodily fluids and make conclusions about epigenetic patterns in inaccessible tissues of interest such as brain, thus neglecting the tissue specificity of epigenetic marks. There is a growing lag between the forefront of epigenetics and the methods routinely applied in epigenetic studies. For instance, while techniques to detect the functionally relevant methylcytosine derivate 5-hydroxymethylcytosine were described years ago, only a few studies use such detection methods.

KW - Journal Article

KW - Review

U2 - 10.1016/j.tips.2017.05.007

DO - 10.1016/j.tips.2017.05.007

M3 - Review

C2 - 28625497

SN - 0165-6147

VL - 38

SP - 765

EP - 770

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 9

ER -