Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review

Sarah Ekeløf; Jacob Rosenberg; Jan Skov Jensen; Ismail Gögenur

doi:10.1007/s12265-014-9574-4

Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review

Sarah Ekeløf, Jacob Rosenberg, Jan Skov Jensen, Ismail Gögenur

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

Originalsprog	Engelsk
Tidsskrift	Journal of Cardiovascular Translational Research
Vol/bind	7
Udgave nummer	6
Sider (fra-til)	570-580
Antal sider	11
ISSN	1937-5387
DOI	https://doi.org/10.1007/s12265-014-9574-4
Status	Udgivet - aug. 2014

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10.1007/s12265-014-9574-4

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title = "Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review",

abstract = "Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.",

keywords = "Animals, Cardiovascular Agents, Disease Models, Animal, Myocardial Reperfusion Injury, Swine, Treatment Outcome",

author = "Sarah Ekel{\o}f and Jacob Rosenberg and Jensen, {Jan Skov} and Ismail G{\"o}genur",

year = "2014",

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AU - Rosenberg, Jacob

AU - Jensen, Jan Skov

AU - Gögenur, Ismail

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AB - Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

KW - Animals

KW - Cardiovascular Agents

KW - Disease Models, Animal

KW - Myocardial Reperfusion Injury

KW - Swine

KW - Treatment Outcome

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JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

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ER -

Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review

Abstract

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