@article{ea05b9e067f011df928f000ea68e967b,
title = "Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes",
abstract = "OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.",
author = "Jensen, {Dorte M} and Lars Korsholm and Per Ovesen and Henning Beck-Nielsen and Lars Moelsted-Pedersen and Westergaard, {Jes G} and Margrethe Moeller and Peter Damm and Dorte Jensen and Lauridsen, {Lars Korsholm} and Ovesen, {Per Glud} and Henning Beck-Nielsen and Lars Moelsted-Pedersen and Westergaard, {Jes G} and Margrethe Moeller and Peter Damm",
note = "Keywords: Body Mass Index; Chromosome Aberrations; Diabetes Mellitus, Type 1; European Continental Ancestry Group; Female; Hemoglobin A, Glycosylated; Humans; Infant, Newborn; Perinatal Mortality; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Retrospective Studies",
year = "2009",
month = jun,
day = "1",
doi = "10.2337/dc08-2061",
language = "English",
volume = "32",
pages = "1046--8",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "6",
}
