Overconsumption and obesity: peptides and susceptibility to weight gain

TY - JOUR

T1 - Overconsumption and obesity

T2 - peptides and susceptibility to weight gain

AU - Blundell, J E

AU - Levin, F

AU - King, N A

AU - Barkeling, B

AU - Gustafsson, T

AU - Gustafson, T

AU - Hellstrom, P M

AU - Holst, Jens Juul

AU - Naslund, E

PY - 2008/8/7

Y1 - 2008/8/7

N2 - Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodically with the consumption of food. These physiological controls are paralleled in the motivation to eat by long-acting enduring traits (such as disinhibition) and by short-acting states (such as hunger). Peptides are usually envisaged to exert an action on appetite control through the modulation of states such as hunger and satiety (fullness). Here we provide evidence that peptides involved in tonic regulation--such as leptin--may express a control over appetite motivation through an effect on traits that confer a constant readiness to eat, whereas episodic peptides such as GLP-1 influence appetite motivation through a state such as hunger. The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain.

AB - Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodically with the consumption of food. These physiological controls are paralleled in the motivation to eat by long-acting enduring traits (such as disinhibition) and by short-acting states (such as hunger). Peptides are usually envisaged to exert an action on appetite control through the modulation of states such as hunger and satiety (fullness). Here we provide evidence that peptides involved in tonic regulation--such as leptin--may express a control over appetite motivation through an effect on traits that confer a constant readiness to eat, whereas episodic peptides such as GLP-1 influence appetite motivation through a state such as hunger. The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain.

KW - Appetite

KW - Female

KW - Humans

KW - Models, Biological

KW - Obesity

KW - Peptides

KW - Weight Gain

U2 - 10.1016/j.regpep.2007.10.009

DO - 10.1016/j.regpep.2007.10.009

M3 - Journal article

C2 - 18534696

SN - 0167-0115

VL - 149

SP - 32

EP - 38

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 1-3

ER -