Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

Lauri Tuominen; Jouko Miettunen; Dara M Cannon; Wayne C Drevets; Vibe G Frokjaer; Jussi Hirvonen; Masanori Ichise; Peter S Jensen; Liisa Keltikangas-Järvinen; Jacqueline M Klaver; Gitte M Knudsen; Akihiro Takano; Tetsuya Suhara; Jarmo Hietala

doi:10.1093/ijnp/pyx071

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

Lauri Tuominen, Jouko Miettunen, Dara M Cannon, Wayne C Drevets, Vibe G Frokjaer, Jussi Hirvonen, Masanori Ichise, Peter S Jensen, Liisa Keltikangas-Järvinen, Jacqueline M Klaver, Gitte M Knudsen, Akihiro Takano, Tetsuya Suhara, Jarmo Hietala

Institut for Klinisk Medicin

9 Citationer (Scopus)

48 Downloads (Pure)

Abstract

Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies.

Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males.

Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014).

Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex.

Originalsprog	Engelsk
Tidsskrift	International Journal of Neuropsychopharmacology
Vol/bind	20
Udgave nummer	12
Sider (fra-til)	963-970
Antal sider	8
ISSN	1461-1457
DOI	https://doi.org/10.1093/ijnp/pyx071
Status	Udgivet - 1 dec. 2017

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10.1093/ijnp/pyx071Licens: CC BY-NC

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and FemalesLicens: CC BY-NC

Citationsformater

Tuominen, L., Miettunen, J., Cannon, D. M., Drevets, W. C., Frokjaer, V. G., Hirvonen, J., Ichise, M., Jensen, P. S., Keltikangas-Järvinen, L., Klaver, J. M., Knudsen, G. M., Takano, A., Suhara, T., & Hietala, J. (2017). Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females. International Journal of Neuropsychopharmacology, 20(12), 963-970. https://doi.org/10.1093/ijnp/pyx071

Tuominen, L, Miettunen, J, Cannon, DM, Drevets, WC, Frokjaer, VG, Hirvonen, J, Ichise, M, Jensen, PS, Keltikangas-Järvinen, L, Klaver, JM, Knudsen, GM, Takano, A, Suhara, T & Hietala, J 2017, 'Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females', International Journal of Neuropsychopharmacology, bind 20, nr. 12, s. 963-970. https://doi.org/10.1093/ijnp/pyx071

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title = "Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females",

abstract = "Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies.Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males.Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014).Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex.",

keywords = "Adolescent, Adult, Cerebral Cortex/diagnostic imaging, Female, Humans, International Cooperation, Male, Middle Aged, Neuroticism, Positron-Emission Tomography, Protein Binding/physiology, Regression Analysis, Serotonin Plasma Membrane Transport Proteins/metabolism, Sex Characteristics, Young Adult",

author = "Lauri Tuominen and Jouko Miettunen and Cannon, {Dara M} and Drevets, {Wayne C} and Frokjaer, {Vibe G} and Jussi Hirvonen and Masanori Ichise and Jensen, {Peter S} and Liisa Keltikangas-J{\"a}rvinen and Klaver, {Jacqueline M} and Knudsen, {Gitte M} and Akihiro Takano and Tetsuya Suhara and Jarmo Hietala",

note = "{\textcopyright} The Author 2017. Published by Oxford University Press on behalf of CINP.",

year = "2017",

month = dec,

day = "1",

doi = "10.1093/ijnp/pyx071",

language = "English",

volume = "20",

pages = "963--970",

journal = "International Journal of Neuropsychopharmacology",

issn = "1461-1457",

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TY - JOUR

T1 - Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

AU - Tuominen, Lauri

AU - Miettunen, Jouko

AU - Cannon, Dara M

AU - Drevets, Wayne C

AU - Frokjaer, Vibe G

AU - Hirvonen, Jussi

AU - Ichise, Masanori

AU - Jensen, Peter S

AU - Keltikangas-Järvinen, Liisa

AU - Klaver, Jacqueline M

AU - Knudsen, Gitte M

AU - Takano, Akihiro

AU - Suhara, Tetsuya

AU - Hietala, Jarmo

N1 - © The Author 2017. Published by Oxford University Press on behalf of CINP.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies.Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males.Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014).Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex.

AB - Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies.Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males.Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014).Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex.

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KW - Adult

KW - Cerebral Cortex/diagnostic imaging

KW - Female

KW - Humans

KW - International Cooperation

KW - Male

KW - Middle Aged

KW - Neuroticism

KW - Positron-Emission Tomography

KW - Protein Binding/physiology

KW - Regression Analysis

KW - Serotonin Plasma Membrane Transport Proteins/metabolism

KW - Sex Characteristics

KW - Young Adult

U2 - 10.1093/ijnp/pyx071

DO - 10.1093/ijnp/pyx071

M3 - Journal article

C2 - 29020405

SN - 1461-1457

VL - 20

SP - 963

EP - 970

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

IS - 12

ER -

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

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