Neuroplastin: cell adhesion molecule and signaling receptor

Sylwia Owczarek; Vladimir Berezin

doi:10.1016/j.biocel.2011.10.006

Neuroplastin: cell adhesion molecule and signaling receptor

Sylwia Owczarek, Vladimir Berezin

Eyepath Lab

15 Citationer (Scopus)

Abstract

Neuroplastin (Np) is a glycoprotein that belongs to the immunoglobulin superfamily of cell adhesion molecules. It exists in two isoforms, Np55 and Np65, named according to their apparent molecular weights. Neuroplastins were first identified as synapse-specific proteins, but subsequent findings have shown that Np65 is indeed expressed only in the brain, whereas Np55 is found in wide range of tissues. Since their discovery, the knowledge of Nps expanded, implicating them in various processes, including neuronal differentiation and synaptic plasticity. Here, we will review the Np structure and mechanisms involved in Np signaling and discuss the functions of Nps in the nervous system.

Originalsprog	Engelsk
Tidsskrift	International Journal of Biochemistry & Cell Biology
Vol/bind	44
Udgave nummer	1
Sider (fra-til)	1-5
Antal sider	5
ISSN	1357-2725
DOI	https://doi.org/10.1016/j.biocel.2011.10.006
Status	Udgivet - jan. 2012

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10.1016/j.biocel.2011.10.006

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title = "Neuroplastin: cell adhesion molecule and signaling receptor",

abstract = "Neuroplastin (Np) is a glycoprotein that belongs to the immunoglobulin superfamily of cell adhesion molecules. It exists in two isoforms, Np55 and Np65, named according to their apparent molecular weights. Neuroplastins were first identified as synapse-specific proteins, but subsequent findings have shown that Np65 is indeed expressed only in the brain, whereas Np55 is found in wide range of tissues. Since their discovery, the knowledge of Nps expanded, implicating them in various processes, including neuronal differentiation and synaptic plasticity. Here, we will review the Np structure and mechanisms involved in Np signaling and discuss the functions of Nps in the nervous system.",

keywords = "Amino Acid Sequence, Animals, Cell Adhesion Molecules, Humans, Membrane Glycoproteins, Models, Molecular, Molecular Sequence Data, Nervous System, Signal Transduction",

author = "Sylwia Owczarek and Vladimir Berezin",

year = "2012",

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language = "English",

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journal = "International Journal of Biochemistry and Cell Biology",

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TY - JOUR

T1 - Neuroplastin

T2 - cell adhesion molecule and signaling receptor

AU - Owczarek, Sylwia

AU - Berezin, Vladimir

PY - 2012/1

Y1 - 2012/1

N2 - Neuroplastin (Np) is a glycoprotein that belongs to the immunoglobulin superfamily of cell adhesion molecules. It exists in two isoforms, Np55 and Np65, named according to their apparent molecular weights. Neuroplastins were first identified as synapse-specific proteins, but subsequent findings have shown that Np65 is indeed expressed only in the brain, whereas Np55 is found in wide range of tissues. Since their discovery, the knowledge of Nps expanded, implicating them in various processes, including neuronal differentiation and synaptic plasticity. Here, we will review the Np structure and mechanisms involved in Np signaling and discuss the functions of Nps in the nervous system.

AB - Neuroplastin (Np) is a glycoprotein that belongs to the immunoglobulin superfamily of cell adhesion molecules. It exists in two isoforms, Np55 and Np65, named according to their apparent molecular weights. Neuroplastins were first identified as synapse-specific proteins, but subsequent findings have shown that Np65 is indeed expressed only in the brain, whereas Np55 is found in wide range of tissues. Since their discovery, the knowledge of Nps expanded, implicating them in various processes, including neuronal differentiation and synaptic plasticity. Here, we will review the Np structure and mechanisms involved in Np signaling and discuss the functions of Nps in the nervous system.

KW - Amino Acid Sequence

KW - Animals

KW - Cell Adhesion Molecules

KW - Humans

KW - Membrane Glycoproteins

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Nervous System

KW - Signal Transduction

U2 - 10.1016/j.biocel.2011.10.006

DO - 10.1016/j.biocel.2011.10.006

M3 - Journal article

C2 - 22036663

SN - 1357-2725

VL - 44

SP - 1

EP - 5

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

IS - 1

ER -

Neuroplastin: cell adhesion molecule and signaling receptor

Abstract

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