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Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins
Naomi L Cook, David I Pattison,
Michael Jonathan Davies
22
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Medicin og biovidenskab
Alcohol Dehydrogenase
77%
Apoptosis
9%
Cysteine
85%
Disulfides
15%
DNA Repair Enzymes
21%
Enzymes
24%
Histidine
100%
hypothiocyanous acid
31%
Inflammation
8%
Ions
24%
Kinetics
10%
Leukocytes
11%
Metals
13%
Necrosis
11%
Nitric Oxide Synthase
14%
Oxidants
94%
Peroxidase
87%
Proteins
33%
Sulfhydryl Compounds
48%
Sulfur Compounds
22%
Transcription Factors
11%
Zinc
86%
Kemiske forbindelser
Acid
7%
Cysteine
19%
Cysteine Residue
47%
Disulfide
18%
Enzyme Activity
37%
Halide
17%
Histidine
85%
Histidine Residue
25%
Ion
8%
Metal Ion
14%
Molecular Cluster
58%
Monomer
13%
Oxidation Reaction
30%
Protein
37%
Protein Structure
44%
Rate Constant
14%
Thiol
57%
Transition Element
16%