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Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins
Naomi L Cook, David I Pattison,
Michael Jonathan Davies
22
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Medicin og biovidenskab
Histidine
100%
Oxidants
94%
Peroxidase
87%
Zinc
86%
Cysteine
85%
Alcohol Dehydrogenase
77%
Sulfhydryl Compounds
48%
Proteins
33%
hypothiocyanous acid
31%
Ions
24%
Enzymes
24%
Sulfur Compounds
22%
DNA Repair Enzymes
21%
Disulfides
15%
Nitric Oxide Synthase
14%
Metals
13%
Leukocytes
11%
Necrosis
11%
Transcription Factors
11%
Kinetics
10%
Apoptosis
9%
Inflammation
8%
Kemiske forbindelser
Histidine
85%
Molecular Cluster
58%
Thiol
57%
Cysteine Residue
47%
Protein Structure
44%
Protein
37%
Enzyme Activity
37%
Oxidation Reaction
30%
Histidine Residue
25%
Cysteine
19%
Disulfide
18%
Halide
17%
Transition Element
16%
Rate Constant
14%
Metal Ion
14%
Monomer
13%
Ion
8%
Acid
7%