Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

J.M. Nygren; K. Liuba; M. Breitbach; S. Stott; Lina Anna Maria Thorén; W. Roell; C. Geisen; P. Sasse; D. Kirik; A. Bjorklund; C. Nerlov; B.K. Fleischmann; S. Jovinge; S.E. Jacobsen

doi:10.1038/ncb1721

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

J.M. Nygren, K. Liuba, M. Breitbach, S. Stott, Lina Anna Maria Thorén, W. Roell, C. Geisen, P. Sasse, D. Kirik, A. Bjorklund, C. Nerlov, B.K. Fleischmann, S. Jovinge, S.E. Jacobsen

121 Citationer (Scopus)

Abstract

Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation
Udgivelsesdato: 2008/5

Originalsprog	Engelsk
Tidsskrift	Nature Cell Biology
Vol/bind	10
Udgave nummer	5
Sider (fra-til)	584-592
Antal sider	8
ISSN	1465-7392
DOI	https://doi.org/10.1038/ncb1721
Status	Udgivet - 2008

Adgang til dokumentet

10.1038/ncb1721

Citationsformater

Nygren, J. M., Liuba, K., Breitbach, M., Stott, S., Thorén, L. A. M., Roell, W., Geisen, C., Sasse, P., Kirik, D., Bjorklund, A., Nerlov, C., Fleischmann, B. K., Jovinge, S., & Jacobsen, S. E. (2008). Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Nature Cell Biology, 10(5), 584-592. https://doi.org/10.1038/ncb1721

Nygren, JM, Liuba, K, Breitbach, M, Stott, S, Thorén, LAM, Roell, W, Geisen, C, Sasse, P, Kirik, D, Bjorklund, A, Nerlov, C, Fleischmann, BK, Jovinge, S & Jacobsen, SE 2008, 'Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion', Nature Cell Biology, bind 10, nr. 5, s. 584-592. https://doi.org/10.1038/ncb1721

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title = "Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion",

abstract = "Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation Udgivelsesdato: 2008/5",

author = "J.M. Nygren and K. Liuba and M. Breitbach and S. Stott and Thor{\'e}n, {Lina Anna Maria} and W. Roell and C. Geisen and P. Sasse and D. Kirik and A. Bjorklund and C. Nerlov and B.K. Fleischmann and S. Jovinge and S.E. Jacobsen",

note = "Keywords: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Fusion; Cell Lineage; Female; Green Fluorescent Proteins; Hematopoietic Stem Cells; Hepatocytes; Lymphocytes; Mice; Mice, SCID; Mice, Transgenic; Muscle, Skeletal; Myeloid Cells; Myocytes, Cardiac; Purkinje Cells; Radiation; Transplantation Chimera",

year = "2008",

doi = "10.1038/ncb1721",

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T1 - Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

AU - Nygren, J.M.

AU - Liuba, K.

AU - Breitbach, M.

AU - Stott, S.

AU - Thorén, Lina Anna Maria

AU - Roell, W.

AU - Geisen, C.

AU - Sasse, P.

AU - Kirik, D.

AU - Bjorklund, A.

AU - Nerlov, C.

AU - Fleischmann, B.K.

AU - Jovinge, S.

AU - Jacobsen, S.E.

N1 - Keywords: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Fusion; Cell Lineage; Female; Green Fluorescent Proteins; Hematopoietic Stem Cells; Hepatocytes; Lymphocytes; Mice; Mice, SCID; Mice, Transgenic; Muscle, Skeletal; Myeloid Cells; Myocytes, Cardiac; Purkinje Cells; Radiation; Transplantation Chimera

PY - 2008

Y1 - 2008

N2 - Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation Udgivelsesdato: 2008/5

AB - Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation Udgivelsesdato: 2008/5

U2 - 10.1038/ncb1721

DO - 10.1038/ncb1721

M3 - Journal article

C2 - 18425115

SN - 1465-7392

VL - 10

SP - 584

EP - 592

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 5

ER -