Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: the way forward

TY - JOUR

T1 - Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis

T2 - the way forward

AU - Kuo, Wieying

AU - Kemner-van de Corput, Mariette P. C.

AU - Perez-Rovira, Adria

AU - de Bruijne, Marleen

AU - Fajac, Isabelle

AU - Tiddens, Harm A. W. M.

AU - van Straten, Marcel

N1 - Copyright ©ERS 2016.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

AB - Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

KW - Journal Article

U2 - 10.1183/13993003.01601-2015

DO - 10.1183/13993003.01601-2015

M3 - Journal article

C2 - 27076593

SN - 0904-1850

VL - 47

SP - 1706

EP - 1717

JO - Acta tuberculosea Scandinavica

JF - Acta tuberculosea Scandinavica

IS - 6

ER -