Mice lacking neuropeptide Y show increased sensitivity to cocaine

TY - JOUR

T1 - Mice lacking neuropeptide Y show increased sensitivity to cocaine

AU - Sørensen, Gunnar

AU - Woldbye, David Paul Drucker

PY - 2012/9

Y1 - 2012/9

N2 - There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.

AB - There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.

U2 - 10.1002/syn.21568

DO - 10.1002/syn.21568

M3 - Journal article

C2 - 22544368

SN - 0887-4476

VL - 66

SP - 840

EP - 843

JO - Synapse

JF - Synapse

ER -