Membrane protein-lipid match and mismatch

TY - CHAP

T1 - Membrane protein-lipid match and mismatch

AU - Mouritsen, O. G.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Lipid-protein interactions are described with a focus on the physical interactions between lipids and integral proteins in lipid-bilayer membranes. The concepts of hydrophobic matching and curvature stress are presented and the effects of match vs mismatch is considered in light of data obtained from experimental and theoretical studies which demonstrate that not only do integral proteins perturb the lipids, but the physical state of the lipids does also actively influence protein function.

AB - Lipid-protein interactions are described with a focus on the physical interactions between lipids and integral proteins in lipid-bilayer membranes. The concepts of hydrophobic matching and curvature stress are presented and the effects of match vs mismatch is considered in light of data obtained from experimental and theoretical studies which demonstrate that not only do integral proteins perturb the lipids, but the physical state of the lipids does also actively influence protein function.

KW - Hydrophobic matching

KW - Hydrophobic thickness

KW - Integral membrane protein

KW - Lipid bilayer

KW - Membrane organization

KW - Structure-function relationship

KW - Wetting

UR - http://www.scopus.com/inward/record.url?scp=84882754080&partnerID=8YFLogxK

U2 - 10.1016/b978-0-12-374920-8.00521-x

DO - 10.1016/b978-0-12-374920-8.00521-x

M3 - Book chapter

AN - SCOPUS:84882754080

SN - 9780080957180

VL - 5

SP - 245

EP - 260

BT - Comprehensive Biophysics

PB - Elsevier Science Inc.

ER -