Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

Natalie L. Halladin; Sarah Victoria Ekeløf Busch; Svend Eggert Jensen; Jens Aarøe; Benedict Kjærgaard; Peter M. H. Heegaard; Jens Lykkesfeldt; Jacob Rosenberg; Ismayil Gögenür

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

Natalie L. Halladin, Sarah Victoria Ekeløf Busch, Svend Eggert Jensen, Jens Aarøe, Benedict Kjærgaard, Peter M. H. Heegaard, Jens Lykkesfeldt, Jacob Rosenberg, Ismayil Gögenür

9 Citationer (Scopus)

Abstract

AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.

MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.

RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.

CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.

Originalsprog	Engelsk
Tidsskrift	In Vivo
Vol/bind	28
Sider (fra-til)	483-488
Antal sider	6
ISSN	0258-851X
Status	Udgivet - 1 jul. 2014

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http://iv.iiarjournals.org/content/28/4/483.short

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title = "Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction",

abstract = "AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.",

author = "Halladin, {Natalie L.} and Busch, {Sarah Victoria Ekel{\o}f} and Jensen, {Svend Eggert} and Jens Aar{\o}e and Benedict Kj{\ae}rgaard and Heegaard, {Peter M. H.} and Jens Lykkesfeldt and Jacob Rosenberg and Ismayil G{\"o}gen{\"u}r",

year = "2014",

month = jul,

day = "1",

language = "English",

volume = "28",

pages = "483--488",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

AU - Halladin, Natalie L.

AU - Busch, Sarah Victoria Ekeløf

AU - Jensen, Svend Eggert

AU - Aarøe, Jens

AU - Kjærgaard, Benedict

AU - Heegaard, Peter M. H.

AU - Lykkesfeldt, Jens

AU - Rosenberg, Jacob

AU - Gögenür, Ismayil

PY - 2014/7/1

Y1 - 2014/7/1

N2 - AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.

AB - AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.

M3 - Journal article

C2 - 24982213

SN - 0258-851X

VL - 28

SP - 483

EP - 488

JO - In Vivo

JF - In Vivo

ER -

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

Abstract

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