Low Number of Detectable Circulating Tumor Cells in Non-metastatic Colon Cancer

Morten Thorsteinsson; György Söletormos; Per Jess

doi:10.1136/ard.2010.137778

Low Number of Detectable Circulating Tumor Cells in Non-metastatic Colon Cancer

Morten Thorsteinsson, György Söletormos, Per Jess

Glycomics Program

42 Citationer (Scopus)

Abstract

Background: The aim of the present study was to detect circulating tumor cells (CTCs) in the peripheral blood of patients with non-metastatic colon cancer and to evaluate whether there is a diurnal variation in the CTC counts. Furthermore, the study aimed to examine the correlation between CTCs and TNM stage, other paraclinical variables and prognosis. Patients and Methods: Blood samples were collected from 20 consecutive patients with colon cancer TNM stage I-III at four different perioperative time points. Detection of CTCs was performed using the immunological assay CellSearch®. Results: CTCs were detected in 1 out of 60 preoperative blood samples, resulting in a detection rate of 1 in 20 patients (5%; 95% confidence interval=0.1-25%). None of the postoperative blood samples had CTC levels above the cut-off value (≥2 CTCs/7.5ml blood). Conclusion: The presence of CTCs in non-metastatic colon cancer is rare and barely detectable with the only commercially available assay for detection of CTCs, the CellSearch System.

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	31
Udgave nummer	2
Sider (fra-til)	613-7
Antal sider	5
DOI	https://doi.org/10.1136/ard.2010.137778
Status	Udgivet - 1 feb. 2011

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10.1136/ard.2010.137778

Citationsformater

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title = "Low Number of Detectable Circulating Tumor Cells in Non-metastatic Colon Cancer",

abstract = "Background: The aim of the present study was to detect circulating tumor cells (CTCs) in the peripheral blood of patients with non-metastatic colon cancer and to evaluate whether there is a diurnal variation in the CTC counts. Furthermore, the study aimed to examine the correlation between CTCs and TNM stage, other paraclinical variables and prognosis. Patients and Methods: Blood samples were collected from 20 consecutive patients with colon cancer TNM stage I-III at four different perioperative time points. Detection of CTCs was performed using the immunological assay CellSearch{\textregistered}. Results: CTCs were detected in 1 out of 60 preoperative blood samples, resulting in a detection rate of 1 in 20 patients (5%; 95% confidence interval=0.1-25%). None of the postoperative blood samples had CTC levels above the cut-off value (≥2 CTCs/7.5ml blood). Conclusion: The presence of CTCs in non-metastatic colon cancer is rare and barely detectable with the only commercially available assay for detection of CTCs, the CellSearch System.",

author = "Morten Thorsteinsson and Gy{\"o}rgy S{\"o}letormos and Per Jess",

year = "2011",

month = feb,

day = "1",

doi = "10.1136/ard.2010.137778",

language = "English",

volume = "31",

pages = "613--7",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Low Number of Detectable Circulating Tumor Cells in Non-metastatic Colon Cancer

AU - Thorsteinsson, Morten

AU - Söletormos, György

AU - Jess, Per

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: The aim of the present study was to detect circulating tumor cells (CTCs) in the peripheral blood of patients with non-metastatic colon cancer and to evaluate whether there is a diurnal variation in the CTC counts. Furthermore, the study aimed to examine the correlation between CTCs and TNM stage, other paraclinical variables and prognosis. Patients and Methods: Blood samples were collected from 20 consecutive patients with colon cancer TNM stage I-III at four different perioperative time points. Detection of CTCs was performed using the immunological assay CellSearch®. Results: CTCs were detected in 1 out of 60 preoperative blood samples, resulting in a detection rate of 1 in 20 patients (5%; 95% confidence interval=0.1-25%). None of the postoperative blood samples had CTC levels above the cut-off value (≥2 CTCs/7.5ml blood). Conclusion: The presence of CTCs in non-metastatic colon cancer is rare and barely detectable with the only commercially available assay for detection of CTCs, the CellSearch System.

AB - Background: The aim of the present study was to detect circulating tumor cells (CTCs) in the peripheral blood of patients with non-metastatic colon cancer and to evaluate whether there is a diurnal variation in the CTC counts. Furthermore, the study aimed to examine the correlation between CTCs and TNM stage, other paraclinical variables and prognosis. Patients and Methods: Blood samples were collected from 20 consecutive patients with colon cancer TNM stage I-III at four different perioperative time points. Detection of CTCs was performed using the immunological assay CellSearch®. Results: CTCs were detected in 1 out of 60 preoperative blood samples, resulting in a detection rate of 1 in 20 patients (5%; 95% confidence interval=0.1-25%). None of the postoperative blood samples had CTC levels above the cut-off value (≥2 CTCs/7.5ml blood). Conclusion: The presence of CTCs in non-metastatic colon cancer is rare and barely detectable with the only commercially available assay for detection of CTCs, the CellSearch System.

U2 - 10.1136/ard.2010.137778

DO - 10.1136/ard.2010.137778

M3 - Journal article

C2 - 21378346

SN - 0250-7005

VL - 31

SP - 613

EP - 617

JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -

Low Number of Detectable Circulating Tumor Cells in Non-metastatic Colon Cancer

Abstract

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