TY - JOUR
T1 - Long-term mortality after Staphylococcus aureus spondylodiscitis
T2 - A Danish nationwide population-based cohort study
AU - Aagaard, Theis
AU - Roed, Casper
AU - Larsen, Anders R
AU - Petersen, Andreas
AU - Dahl, Benny
AU - Skinhøj, Peter
AU - Obel, Niels
AU - Danish Staphylococcal Bacteraemia Study Group
N1 - Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
PY - 2014/9
Y1 - 2014/9
N2 - Objectives: To determine the long-term mortality and the causes of death after Staphylococcus aureus spondylodiscitis. Methods: Nationwide, population-based cohort study using national registries of adults diagnosed with non-postoperative S. aureus spondylodiscitis from 1994-2009 and alive 1 year after diagnosis (n=313). A comparison cohort from the background population individually matched on sex and age was identified (n=1565). Kaplan-Meier survival curves were constructed and Poisson regression analyses used to estimate mortality rate ratios (MRR) adjusted for comorbidity. Results: 88 patients (28.1%) and 267 individuals from the population-based comparison cohort(17.1%) died. Un-adjusted MRR for S. aureus spondylodiscitis patients was 1.77 (95% CI, 1.39-2.25) and 1.32 (95% CI, 1.02-1.71) after adjustment for comorbidity. We observed increasedmortality due to infectious (MRR 8.57; 95% CI, 2.80-26.20), endocrine (MRR 3.57; 95% CI, 1.01-12.66), cardiovascular (MRR 1.59; 95% CI, 1.02-2.49), gastrointestinal (MRR3.21; 95% CI, 1.17-8.84) and alcohol and drug abuse-related (MRR 10.71; 95% CI, 3.23-35.58) diseases. Conclusions: Patients diagnosed with S. aureus spondylodiscitis have substantially increased long-term mortality, mainly due to comorbidity. To improve survival after S. aureus spondylodiscitis these patients should be screened for comorbidity and substance abuse predisposing to the disease.
AB - Objectives: To determine the long-term mortality and the causes of death after Staphylococcus aureus spondylodiscitis. Methods: Nationwide, population-based cohort study using national registries of adults diagnosed with non-postoperative S. aureus spondylodiscitis from 1994-2009 and alive 1 year after diagnosis (n=313). A comparison cohort from the background population individually matched on sex and age was identified (n=1565). Kaplan-Meier survival curves were constructed and Poisson regression analyses used to estimate mortality rate ratios (MRR) adjusted for comorbidity. Results: 88 patients (28.1%) and 267 individuals from the population-based comparison cohort(17.1%) died. Un-adjusted MRR for S. aureus spondylodiscitis patients was 1.77 (95% CI, 1.39-2.25) and 1.32 (95% CI, 1.02-1.71) after adjustment for comorbidity. We observed increasedmortality due to infectious (MRR 8.57; 95% CI, 2.80-26.20), endocrine (MRR 3.57; 95% CI, 1.01-12.66), cardiovascular (MRR 1.59; 95% CI, 1.02-2.49), gastrointestinal (MRR3.21; 95% CI, 1.17-8.84) and alcohol and drug abuse-related (MRR 10.71; 95% CI, 3.23-35.58) diseases. Conclusions: Patients diagnosed with S. aureus spondylodiscitis have substantially increased long-term mortality, mainly due to comorbidity. To improve survival after S. aureus spondylodiscitis these patients should be screened for comorbidity and substance abuse predisposing to the disease.
U2 - 10.1016/j.jinf.2014.03.017
DO - 10.1016/j.jinf.2014.03.017
M3 - Journal article
C2 - 24844824
SN - 0163-4453
VL - 69
SP - 252
EP - 258
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -
