TY - JOUR
T1 - Local administration of growth hormone stimulates tendon collagen synthesis in elderly men
AU - Vestergaard, Poul Erik
AU - Jørgensen, Jens Otto Lunde
AU - Olesen, Jens
AU - Bosnjak, Ermina
AU - Holm, Lars
AU - Frystyk, Jan
AU - Langberg, Henning
AU - Kjaer, Michael
AU - Hansen, Mette Damborg
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.
AB - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.
U2 - 10.1152/japplphysiol.00816.2012
DO - 10.1152/japplphysiol.00816.2012
M3 - Journal article
C2 - 22961272
SN - 8750-7587
VL - 113
SP - 1432
EP - 1438
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 9
ER -