Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance

Malin Plumhoff Tygesen; Mette Olaf Nielsen; Peder Nørgaard; Hans Ranvig; Adrian Paul Harrison; Anne-Helene Tauson

doi:10.1080/17450390701780276

Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance

Malin Plumhoff Tygesen, Mette Olaf Nielsen, Peder Nørgaard, Hans Ranvig, Adrian Paul Harrison, Anne-Helene Tauson

Abstract

We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, beta-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite ad libitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.

Originalsprog	Engelsk
Tidsskrift	Archives of Animal Nutrition
Vol/bind	62
Udgave nummer	1
Sider (fra-til)	44-59
Antal sider	16
ISSN	1745-039X
DOI	https://doi.org/10.1080/17450390701780276
Status	Udgivet - feb. 2008

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10.1080/17450390701780276

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Late gestational nutrient restriction : effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance. / Tygesen, Malin Plumhoff; Nielsen, Mette Olaf ; Nørgaard, Peder et al.

I: Archives of Animal Nutrition, Bind 62, Nr. 1, 02.2008, s. 44-59.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance",

abstract = "We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, beta-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite ad libitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.",

keywords = "3-Hydroxybutyric Acid, Adaptation, Physiological, Animal Feed, Animal Nutritional Physiological Phenomena, Animals, Birth Weight, Blood Glucose, Caloric Restriction, Fatty Acids, Nonesterified, Female, Insulin, Insulin-Like Growth Factor I, Lactation, Leptin, Milk, Pregnancy, Pregnancy, Animal, Random Allocation, Sheep, Journal Article, Research Support, Non-U.S. Gov't",

author = "Tygesen, {Malin Plumhoff} and Nielsen, {Mette Olaf} and Peder N{\o}rgaard and Hans Ranvig and Harrison, {Adrian Paul} and Anne-Helene Tauson",

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AU - Nielsen, Mette Olaf

AU - Nørgaard, Peder

AU - Ranvig, Hans

AU - Harrison, Adrian Paul

AU - Tauson, Anne-Helene

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N2 - We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, beta-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite ad libitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.

AB - We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, beta-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite ad libitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.

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KW - Insulin

KW - Insulin-Like Growth Factor I

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KW - Pregnancy

KW - Pregnancy, Animal

KW - Random Allocation

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Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance

Abstract

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