Isothiazolinones in commercial products at Danish workplaces

Ulrik Fischer Friis; Torkil Menné; Mari-Ann Flyvholm; Jens Peter Ellekilde Bonde; Jean-Pierre Lepoittevin; Christophe J Le Coz; Jeanne Duus Johansen

doi:10.1111/cod.12235

Isothiazolinones in commercial products at Danish workplaces

Ulrik Fischer Friis, Torkil Menné, Mari-Ann Flyvholm, Jens Peter Ellekilde Bonde, Jean-Pierre Lepoittevin, Christophe J Le Coz, Jeanne Duus Johansen

48 Citationer (Scopus)

Abstract

BACKGROUND: In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several European countries.

OBJECTIVE: To examine the extent and occurrence of isothiazolinones in different types of product at Danish workplaces.

METHODS: Seven different isothiazolinones were identified in the Dictionary of Contact Allergens: Chemical Structures, Sources, and References from Kanerva's Occupational Dermatitis. By use of the chemical names and Chemical Abstracts Service numbers for these chemicals, information on products registered in the Danish Product Register Database (PROBAS) was obtained.

RESULTS: All seven isothiazolinones were registered in PROBAS. The top three isothiazolinones registered were: benzisothiazolinone (BIT), registered in 985 products, methylisothiazolinone (MI), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01 ppm to 45% for BIT, 0.01 ppm to 10% for MI, and 0.01 ppm to 14.1% for MCI/MI. The most common product type was 'paint and varnish'; five of the seven isothiazolinones were registered in this type of product.

CONCLUSION: Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	71
Udgave nummer	2
Sider (fra-til)	65-74
Antal sider	10
ISSN	0105-1873
DOI	https://doi.org/10.1111/cod.12235
Status	Udgivet - aug. 2014

Adgang til dokumentet

10.1111/cod.12235

Citationsformater

@article{be7ef10485f24606a9f1a75b852f82fe,

title = "Isothiazolinones in commercial products at Danish workplaces",

abstract = "BACKGROUND: In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several European countries.OBJECTIVE: To examine the extent and occurrence of isothiazolinones in different types of product at Danish workplaces.METHODS: Seven different isothiazolinones were identified in the Dictionary of Contact Allergens: Chemical Structures, Sources, and References from Kanerva's Occupational Dermatitis. By use of the chemical names and Chemical Abstracts Service numbers for these chemicals, information on products registered in the Danish Product Register Database (PROBAS) was obtained.RESULTS: All seven isothiazolinones were registered in PROBAS. The top three isothiazolinones registered were: benzisothiazolinone (BIT), registered in 985 products, methylisothiazolinone (MI), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01 ppm to 45% for BIT, 0.01 ppm to 10% for MI, and 0.01 ppm to 14.1% for MCI/MI. The most common product type was 'paint and varnish'; five of the seven isothiazolinones were registered in this type of product.CONCLUSION: Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.",

keywords = "Construction Materials, Cosmetics, Dermatitis, Allergic Contact, Dermatitis, Occupational, Household Products, Humans, Preservatives, Pharmaceutical, Sulfhydryl Compounds, Thiazoles, Workplace",

author = "Friis, {Ulrik Fischer} and Torkil Menn{\'e} and Mari-Ann Flyvholm and Bonde, {Jens Peter Ellekilde} and Jean-Pierre Lepoittevin and {Le Coz}, {Christophe J} and Johansen, {Jeanne Duus}",

note = "{\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2014",

month = aug,

doi = "10.1111/cod.12235",

language = "English",

volume = "71",

pages = "65--74",

journal = "Contact Dermatitis",

issn = "0105-1873",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Isothiazolinones in commercial products at Danish workplaces

AU - Friis, Ulrik Fischer

AU - Menné, Torkil

AU - Flyvholm, Mari-Ann

AU - Bonde, Jens Peter Ellekilde

AU - Lepoittevin, Jean-Pierre

AU - Le Coz, Christophe J

AU - Johansen, Jeanne Duus

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several European countries.OBJECTIVE: To examine the extent and occurrence of isothiazolinones in different types of product at Danish workplaces.METHODS: Seven different isothiazolinones were identified in the Dictionary of Contact Allergens: Chemical Structures, Sources, and References from Kanerva's Occupational Dermatitis. By use of the chemical names and Chemical Abstracts Service numbers for these chemicals, information on products registered in the Danish Product Register Database (PROBAS) was obtained.RESULTS: All seven isothiazolinones were registered in PROBAS. The top three isothiazolinones registered were: benzisothiazolinone (BIT), registered in 985 products, methylisothiazolinone (MI), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01 ppm to 45% for BIT, 0.01 ppm to 10% for MI, and 0.01 ppm to 14.1% for MCI/MI. The most common product type was 'paint and varnish'; five of the seven isothiazolinones were registered in this type of product.CONCLUSION: Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.

AB - BACKGROUND: In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several European countries.OBJECTIVE: To examine the extent and occurrence of isothiazolinones in different types of product at Danish workplaces.METHODS: Seven different isothiazolinones were identified in the Dictionary of Contact Allergens: Chemical Structures, Sources, and References from Kanerva's Occupational Dermatitis. By use of the chemical names and Chemical Abstracts Service numbers for these chemicals, information on products registered in the Danish Product Register Database (PROBAS) was obtained.RESULTS: All seven isothiazolinones were registered in PROBAS. The top three isothiazolinones registered were: benzisothiazolinone (BIT), registered in 985 products, methylisothiazolinone (MI), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01 ppm to 45% for BIT, 0.01 ppm to 10% for MI, and 0.01 ppm to 14.1% for MCI/MI. The most common product type was 'paint and varnish'; five of the seven isothiazolinones were registered in this type of product.CONCLUSION: Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.

KW - Construction Materials

KW - Cosmetics

KW - Dermatitis, Allergic Contact

KW - Dermatitis, Occupational

KW - Household Products

KW - Humans

KW - Preservatives, Pharmaceutical

KW - Sulfhydryl Compounds

KW - Thiazoles

KW - Workplace

U2 - 10.1111/cod.12235

DO - 10.1111/cod.12235

M3 - Journal article

C2 - 24850171

SN - 0105-1873

VL - 71

SP - 65

EP - 74

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 2

ER -

Isothiazolinones in commercial products at Danish workplaces

Abstract

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