Irritable bowel syndrome, the microbiota and the gut-brain axis

Hans Raskov; Jakob Burcharth; Hans-Christian Pommergaard; Jacob Rosenberg

doi:10.1080/19490976.2016.1218585

Irritable bowel syndrome, the microbiota and the gut-brain axis

Hans Raskov, Jakob Burcharth, Hans-Christian Pommergaard, Jacob Rosenberg

Institut for Klinisk Medicin

37 Citationer (Scopus)

Abstract

Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.

Originalsprog	Engelsk
Tidsskrift	Gut Microbes
Vol/bind	7
Udgave nummer	5
Sider (fra-til)	365-383
Antal sider	19
ISSN	1949-0976
DOI	https://doi.org/10.1080/19490976.2016.1218585
Status	Udgivet - 2 sep. 2016

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10.1080/19490976.2016.1218585

19490976.2016.1218585?needAccess=trueForlagets udgivne version, 1,05 MB

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Irritable bowel syndrome, the microbiota and the gut-brain axis

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