Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Marli A Robertson; David L Sigalet; Jens Juul Holst; Jon B Meddings; Julie Wood; Keith A Sharkey

doi:10.1007/s10803-007-0482-1

Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Marli A Robertson, David L Sigalet, Jens Juul Holst, Jon B Meddings, Julie Wood, Keith A Sharkey

Endocrinology and Metabolism

34 Citationer (Scopus)

Abstract

We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.

Originalsprog	Engelsk
Tidsskrift	Journal of Autism and Developmental Disorders
Vol/bind	38
Udgave nummer	6
Sider (fra-til)	1066-71
Antal sider	6
ISSN	0162-3257
DOI	https://doi.org/10.1007/s10803-007-0482-1
Status	Udgivet - jul. 2008

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10.1007/s10803-007-0482-1

Citationsformater

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AU - Sigalet, David L

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AU - Meddings, Jon B

AU - Wood, Julie

AU - Sharkey, Keith A

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KW - Child, Preschool

KW - Female

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Intestinal Absorption

KW - Intestine, Small

KW - Lactulose

KW - Male

KW - Mannitol

KW - Pilot Projects

KW - Reference Values

KW - Satiety Response

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JF - Journal of Autism and Developmental Disorders

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Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Abstract

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