Interactions of the humoral pattern recognition molecule PTX3 with the complement system

TY - JOUR

T1 - Interactions of the humoral pattern recognition molecule PTX3 with the complement system

AU - Doni, Andrea

AU - Garlanda, Cecilia

AU - Bottazzi, Barbara

AU - Meri, Seppo

AU - Garred, Peter

AU - Mantovani, Alberto

N1 - Copyright © 2012 Elsevier GmbH. All rights reserved.

PY - 2012/11

Y1 - 2012/11

N2 - The innate immune system comprises a cellular and a humoral arm. The long pentraxin PTX3 is a fluid phase pattern recognition molecule, which acts as an essential component of the humoral arm of innate immunity. PTX3 has antibody-like properties including interactions with complement components. PTX3 interacts with C1q, ficolin-1 and ficolin-2 as well as mannose-binding lectin, recognition molecules in the classical and lectin complement pathways. The formation of these heterocomplexes results in cooperative pathogen recognition and complement activation. Interactions with C4b binding protein and factor H, the principal regulators of the classical, lectin and alternative complement pathways, show that PTX3 also may have a major influence on the regulation of the complement system. The complex interaction of PTX3 with the complement system at different levels has broad implications for host defence and regulation of inflammation.

AB - The innate immune system comprises a cellular and a humoral arm. The long pentraxin PTX3 is a fluid phase pattern recognition molecule, which acts as an essential component of the humoral arm of innate immunity. PTX3 has antibody-like properties including interactions with complement components. PTX3 interacts with C1q, ficolin-1 and ficolin-2 as well as mannose-binding lectin, recognition molecules in the classical and lectin complement pathways. The formation of these heterocomplexes results in cooperative pathogen recognition and complement activation. Interactions with C4b binding protein and factor H, the principal regulators of the classical, lectin and alternative complement pathways, show that PTX3 also may have a major influence on the regulation of the complement system. The complex interaction of PTX3 with the complement system at different levels has broad implications for host defence and regulation of inflammation.

U2 - 10.1016/j.imbio.2012.07.004

DO - 10.1016/j.imbio.2012.07.004

M3 - Journal article

C2 - 22964239

SN - 0171-2985

VL - 217

SP - 1122

EP - 1128

JO - Immunobiology

JF - Immunobiology

IS - 11

ER -