TY - JOUR
T1 - Integrin signaling to the actin cytoskeleton
AU - DeMali, Kris A
AU - Wennerberg, Krister
AU - Burridge, Keith
PY - 2003/10
Y1 - 2003/10
N2 - Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.
AB - Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.
KW - Actins/metabolism
KW - Animals
KW - Cyclic AMP-Dependent Protein Kinases
KW - Cytoskeleton/metabolism
KW - Enzyme Activation/physiology
KW - Humans
KW - Integrins/metabolism
KW - Phosphatidylinositol 4,5-Diphosphate
KW - Phosphatidylinositol Phosphates/metabolism
KW - Protein Kinase C/metabolism
KW - Protein Tyrosine Phosphatases/metabolism
KW - Protein-Serine-Threonine Kinases/metabolism
KW - Signal Transduction/physiology
KW - cdc42 GTP-Binding Protein/metabolism
KW - rac GTP-Binding Proteins/metabolism
KW - rho GTP-Binding Proteins/metabolism
M3 - Review
C2 - 14519392
SN - 0955-0674
VL - 15
SP - 572
EP - 582
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -