Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study

TY - JOUR

T1 - Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study

AU - Egeberg, Rikke

AU - Olsen, Anja

AU - Christensen, Jane

AU - Johnsen, Nina Føns

AU - Loft, Steffen

AU - Overvad, Kim

AU - Tjønneland, Anne

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Objective: High intake of whole-grain products may protect against prostate cancer, but overall evidence is limited and inconclusive. The aim of the present study was to investigate the relationship between the intake of wholegrain products and risk of prostate cancer in a large prospective cohort. Methods: A total of 26,691 men aged 50-64 years participated in the Diet, Cancer and Health cohort study and provided information about diet and potential prostate cancer risk factors. During a median follow-up of 12.4 years, we identified 1,081 prostate cancer cases. Associations between whole-grain product intake and prostate cancer incidence were analyzed using Cox's regression model. Results: Overall, there was no association between total intake of whole-grain products and prostate cancer risk (adjusted incidence rate ratio per 50 g day-1: 1.00 (95% confidence interval: 0.96, 1.05)) as well as between intake of the specific whole-grain products: whole-grain rye bread, whole-grain bread, and oatmeal, and risk of prostate cancer. No risk estimates did differ according to either stage or grade of disease. Conclusions: Results from this prospective study suggest that higher intakes of total or specific whole-grain products are not associated with risk of prostate cancer in a population of Danish middle-aged men.

AB - Objective: High intake of whole-grain products may protect against prostate cancer, but overall evidence is limited and inconclusive. The aim of the present study was to investigate the relationship between the intake of wholegrain products and risk of prostate cancer in a large prospective cohort. Methods: A total of 26,691 men aged 50-64 years participated in the Diet, Cancer and Health cohort study and provided information about diet and potential prostate cancer risk factors. During a median follow-up of 12.4 years, we identified 1,081 prostate cancer cases. Associations between whole-grain product intake and prostate cancer incidence were analyzed using Cox's regression model. Results: Overall, there was no association between total intake of whole-grain products and prostate cancer risk (adjusted incidence rate ratio per 50 g day-1: 1.00 (95% confidence interval: 0.96, 1.05)) as well as between intake of the specific whole-grain products: whole-grain rye bread, whole-grain bread, and oatmeal, and risk of prostate cancer. No risk estimates did differ according to either stage or grade of disease. Conclusions: Results from this prospective study suggest that higher intakes of total or specific whole-grain products are not associated with risk of prostate cancer in a population of Danish middle-aged men.

U2 - 10.1007/s10552-011-9789-5

DO - 10.1007/s10552-011-9789-5

M3 - Journal article

C2 - 21656162

SN - 0957-5243

VL - 22

SP - 1133

EP - 1139

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 8

ER -