Induction of oxygen free radical generation in human monocytes by lipoprotein(a)

TY - JOUR

T1 - Induction of oxygen free radical generation in human monocytes by lipoprotein(a)

AU - Riis Hansen, P

AU - Kharazmi, A

AU - Jauhiainen, M

AU - Ehnholm, C

N1 - Keywords: Chemiluminescent Measurements; Female; Humans; Lipoprotein(a); Male; Monocytes; Reactive Oxygen Species; Respiratory Burst

PY - 1994

Y1 - 1994

N2 - The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)] levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.

AB - The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)] levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.

M3 - Journal article

C2 - 7957508

SN - 0014-2972

VL - 24

SP - 497

EP - 499

JO - Zeitschrift fur klinische Medizin

JF - Zeitschrift fur klinische Medizin

IS - 7

ER -