Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients

P Skinhøj; B Hofmann; K D Jacobsen; B Lerche; B Frederiksen; Ib Christian Bygbjerg; C S Petersen; E Dickmeiss; A Svejgaard

Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients

P Skinhøj, B Hofmann, K D Jacobsen, B Lerche, B Frederiksen, Ib Christian Bygbjerg, C S Petersen, E Dickmeiss, A Svejgaard

LUKKET: Institut for Immunologi og Mikrobiologi

4 Citationer (Scopus)

Abstract

HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Infectious Diseases
Vol/bind	21
Udgave nummer	2
Sider (fra-til)	149-53
Antal sider	5
ISSN	0036-5548
Status	Udgivet - 1 jan. 1989

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Citationsformater

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title = "Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients",

abstract = "HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.",

keywords = "Antigens, Differentiation, T-Lymphocyte, HIV Antibodies, HIV Antigens, HIV Seropositivity, Humans, Leukocyte Count, Lymphocytes, Predictive Value of Tests, Prognosis, Risk Factors",

author = "P Skinh{\o}j and B Hofmann and Jacobsen, {K D} and B Lerche and B Frederiksen and Bygbjerg, {Ib Christian} and Petersen, {C S} and E Dickmeiss and A Svejgaard",

year = "1989",

month = jan,

day = "1",

language = "English",

volume = "21",

pages = "149--53",

journal = "Infectious Diseases",

issn = "2374-4235",

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}

TY - JOUR

T1 - Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients

AU - Skinhøj, P

AU - Hofmann, B

AU - Jacobsen, K D

AU - Lerche, B

AU - Frederiksen, B

AU - Bygbjerg, Ib Christian

AU - Petersen, C S

AU - Dickmeiss, E

AU - Svejgaard, A

PY - 1989/1/1

Y1 - 1989/1/1

N2 - HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.

AB - HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.

KW - Antigens, Differentiation, T-Lymphocyte

KW - HIV Antibodies

KW - HIV Antigens

KW - HIV Seropositivity

KW - Humans

KW - Leukocyte Count

KW - Lymphocytes

KW - Predictive Value of Tests

KW - Prognosis

KW - Risk Factors

M3 - Journal article

C2 - 2786246

SN - 2374-4235

VL - 21

SP - 149

EP - 153

JO - Infectious Diseases

JF - Infectious Diseases

IS - 2

ER -

Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients

Abstract

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