TY - JOUR
T1 - Impaired cutaneous wound healing in mice lacking tetranectin
AU - Iba, Kousuke
AU - Hatakeyama, Naoko
AU - Kojima, Takashi
AU - Murata, Masaki
AU - Matsumura, Tadaki
AU - Wewer, Ulla M
AU - Wada, Takuro
AU - Sawada, Norimasa
AU - Yamashita, Toshihiko
N1 - Keywords: Animals; Lectins, C-Type; Male; Mice; Models, Animal; Reverse Transcriptase Polymerase Chain Reaction; Skin; Wound Healing
PY - 2009
Y1 - 2009
N2 - Tetranectin was originally purified from human serum on the basis of plasminogen kringle 4-binding properties. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. We have generated mice with a targeted disruption of the tetranectin gene to elucidate the biological function of tetranectin. In this study, we showed that wound healing was markedly delayed in tetranectin-null mice compared with wild-type mice. A single full-thickness incision was made in the dorsal skin. By 14 days after the incision, the wounds fully healed in all wild-type mice based on the macroscopic closure; in contrast, the progress of wound healing in the tetranectin null mice appeared to be impaired. In histological analysis, wounds of wild-type mice showed complete reepithelialization and healed by 14 days after the incision. However, those of tetranectin-null mice never showed complete reepithelialization at 14 days. At 21 days after the injury, the wound healed and was covered with an epidermis. These results supported the fact that tetranectin may play a role in the wound healing process.
AB - Tetranectin was originally purified from human serum on the basis of plasminogen kringle 4-binding properties. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. We have generated mice with a targeted disruption of the tetranectin gene to elucidate the biological function of tetranectin. In this study, we showed that wound healing was markedly delayed in tetranectin-null mice compared with wild-type mice. A single full-thickness incision was made in the dorsal skin. By 14 days after the incision, the wounds fully healed in all wild-type mice based on the macroscopic closure; in contrast, the progress of wound healing in the tetranectin null mice appeared to be impaired. In histological analysis, wounds of wild-type mice showed complete reepithelialization and healed by 14 days after the incision. However, those of tetranectin-null mice never showed complete reepithelialization at 14 days. At 21 days after the injury, the wound healed and was covered with an epidermis. These results supported the fact that tetranectin may play a role in the wound healing process.
U2 - 10.1111/j.1524-475X.2008.00447.x
DO - 10.1111/j.1524-475X.2008.00447.x
M3 - Journal article
C2 - 19152657
SN - 1067-1927
VL - 17
SP - 108
EP - 112
JO - Wound Repair and Regeneration
JF - Wound Repair and Regeneration
IS - 1
ER -