Immunologic mapping of glycomes: implications for cancer diagnosis and therapy

TY - JOUR

T1 - Immunologic mapping of glycomes: implications for cancer diagnosis and therapy

AU - Zhou, Dapeng

AU - Levery, Steven B

AU - Hsu, Fong-Fu

AU - Wang, Peng G

AU - Teneberg, Susann

AU - Almeida, Igor C

AU - Li, Yunsen

AU - Xu, Huaxi

AU - Wang, Lai-Xi

AU - Xia, Chengfeng

AU - Ibrahim, Nuhad K

AU - Michael, Katja

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

AB - Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

M3 - Journal article

C2 - 21622287

SN - 1945-0516

VL - 3

SP - 1520

EP - 1532

JO - Frontiers in Bioscience - Scholar

JF - Frontiers in Bioscience - Scholar

ER -