In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Anne Vested; Cecilia H Ramlau-Hansen; Sjurdur F Olsen; Jens Peter Bonde; Henrik Støvring; Susanne L Kristensen; Thorhallur I Halldorsson; Panu Rantakokko; Hannu Kiviranta; Emil H Ernst; Gunnar Toft

doi:10.1530/REP-13-0488

In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Anne Vested, Cecilia H Ramlau-Hansen, Sjurdur F Olsen, Jens Peter Bonde, Henrik Støvring, Susanne L Kristensen, Thorhallur I Halldorsson, Panu Rantakokko, Hannu Kiviranta, Emil H Ernst, Gunnar Toft

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Abstract

Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p 0 -dichlorodiphenyldichloroethylene (p ,p 0 -DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008-2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988-1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p 0 -DDE. The potential associations between in utero exposure to SPCBs (pmol/ml), Sdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p 0 -DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of SPCB, SDL-PCB, and p,p 0 -DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to SPCB, SDL-PCB, and p,p 0 -DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p 0 -DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.

Originalsprog	Engelsk
Tidsskrift	Reproduction
Vol/bind	148
Udgave nummer	6
Sider (fra-til)	635-646
Antal sider	12
ISSN	1470-1626
DOI	https://doi.org/10.1530/REP-13-0488
Status	Udgivet - 1 dec. 2014

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title = "In utero exposure to persistent organochlorine pollutants and reproductive health in the human male",

abstract = "Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p 0 -dichlorodiphenyldichloroethylene (p ,p 0 -DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008-2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988-1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p 0 -DDE. The potential associations between in utero exposure to SPCBs (pmol/ml), Sdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p 0 -DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of SPCB, SDL-PCB, and p,p 0 -DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to SPCB, SDL-PCB, and p,p 0 -DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p 0 -DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.",

author = "Anne Vested and Ramlau-Hansen, {Cecilia H} and Olsen, {Sjurdur F} and Bonde, {Jens Peter} and Henrik St{\o}vring and Kristensen, {Susanne L} and Halldorsson, {Thorhallur I} and Panu Rantakokko and Hannu Kiviranta and Ernst, {Emil H} and Gunnar Toft",

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doi = "10.1530/REP-13-0488",

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journal = "Reproduction",

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T1 - In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

AU - Vested, Anne

AU - Ramlau-Hansen, Cecilia H

AU - Olsen, Sjurdur F

AU - Bonde, Jens Peter

AU - Støvring, Henrik

AU - Kristensen, Susanne L

AU - Halldorsson, Thorhallur I

AU - Rantakokko, Panu

AU - Kiviranta, Hannu

AU - Ernst, Emil H

AU - Toft, Gunnar

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p 0 -dichlorodiphenyldichloroethylene (p ,p 0 -DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008-2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988-1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p 0 -DDE. The potential associations between in utero exposure to SPCBs (pmol/ml), Sdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p 0 -DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of SPCB, SDL-PCB, and p,p 0 -DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to SPCB, SDL-PCB, and p,p 0 -DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p 0 -DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.

AB - Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p 0 -dichlorodiphenyldichloroethylene (p ,p 0 -DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008-2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988-1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p 0 -DDE. The potential associations between in utero exposure to SPCBs (pmol/ml), Sdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p 0 -DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of SPCB, SDL-PCB, and p,p 0 -DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to SPCB, SDL-PCB, and p,p 0 -DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p 0 -DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.

U2 - 10.1530/REP-13-0488

DO - 10.1530/REP-13-0488

M3 - Journal article

C2 - 25190505

SN - 1470-1626

VL - 148

SP - 635

EP - 646

JO - Reproduction

JF - Reproduction

IS - 6

ER -

In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

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