Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

Jacob Pontoppidan Thyssen; Torkil Menné; Jesper Elberling; Peter Plaschke; Jeanne Duus Johansen

doi:http://dx.doi.org/10.1111/j.1600-0536.2008.01366.x

Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

Jacob Pontoppidan Thyssen, Torkil Menné, Jesper Elberling, Peter Plaschke, Jeanne Duus Johansen

76 Citationer (Scopus)

Abstract

Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered. Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	59
Udgave nummer	2
Sider (fra-til)	69-78
Antal sider	10
ISSN	0105-1873
DOI	https://doi.org/10.1111/j.1600-0536.2008.01366.x
Status	Udgivet - 2008

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Citationsformater

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abstract = "Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered. Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions.",

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T1 - Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

AU - Thyssen, Jacob Pontoppidan

AU - Menné, Torkil

AU - Elberling, Jesper

AU - Plaschke, Peter

AU - Johansen, Jeanne Duus

PY - 2008

Y1 - 2008

N2 - Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered. Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions.

AB - Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered. Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions.

U2 - http://dx.doi.org/10.1111/j.1600-0536.2008.01366.x

DO - http://dx.doi.org/10.1111/j.1600-0536.2008.01366.x

M3 - Journal article

SN - 0105-1873

VL - 59

SP - 69

EP - 78

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 2

ER -

Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

Abstract

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