Historical exposure to persistent organic pollutants and risk of incident hypertension

TY - JOUR

T1 - Historical exposure to persistent organic pollutants and risk of incident hypertension

AU - Arrebola, Juan P

AU - Fernández, Mariana F

AU - Martin-Olmedo, Piedad

AU - Bonde, Jens Peter

AU - Martín-Rodriguez, José L

AU - Expósito, José

AU - Rubio-Domínguez, Antonio

AU - Olea, Nicolás

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The aim of this study was to assess the influence of adipose tissue concentrations of a group of persistent organic pollutants (POPs) on the risk of hypertension in an adult cohort of residents of Granada (Southern Spain) over a 10-year follow-up. No chemical was significantly associated with the risk of hypertension in the overall population or when models were stratified by sex or median age. However, we found positive associations between log-transformed POP concentrations and hypertension risk in participants with body mass index (BMI) above the median value of 26.3kg/m2, which were statistically significant for hexachlorobenzene (HR=1.26, 95% CI=1.03-1.56), β-hexachlorocyclohexane (HR=1.25, 95% CI=1.03-1.51), and polychlorinated biphenyl congeners -138 (HR=1.32, 95% CI=1.04-1.69) and -153 (HR=1.36, 95% CI=1.00-1.84). Inverse associations were observed in the subgroup with BMI≤26.3kg/m2, but none was statistically significant. More research and a longer follow-up period are warranted to verify these associations and elucidate the role of obesity as a potential effect modifier. Given the elevated worldwide frequency of POP exposure and hypertension, the public health impact of this relationship may be substantial.

AB - The aim of this study was to assess the influence of adipose tissue concentrations of a group of persistent organic pollutants (POPs) on the risk of hypertension in an adult cohort of residents of Granada (Southern Spain) over a 10-year follow-up. No chemical was significantly associated with the risk of hypertension in the overall population or when models were stratified by sex or median age. However, we found positive associations between log-transformed POP concentrations and hypertension risk in participants with body mass index (BMI) above the median value of 26.3kg/m2, which were statistically significant for hexachlorobenzene (HR=1.26, 95% CI=1.03-1.56), β-hexachlorocyclohexane (HR=1.25, 95% CI=1.03-1.51), and polychlorinated biphenyl congeners -138 (HR=1.32, 95% CI=1.04-1.69) and -153 (HR=1.36, 95% CI=1.00-1.84). Inverse associations were observed in the subgroup with BMI≤26.3kg/m2, but none was statistically significant. More research and a longer follow-up period are warranted to verify these associations and elucidate the role of obesity as a potential effect modifier. Given the elevated worldwide frequency of POP exposure and hypertension, the public health impact of this relationship may be substantial.

KW - Adipose Tissue

KW - Adult

KW - Aged

KW - Blood Pressure

KW - Body Mass Index

KW - Environmental Exposure

KW - Environmental Monitoring

KW - Environmental Pollutants

KW - Female

KW - Humans

KW - Hydrocarbons, Chlorinated

KW - Hypertension

KW - Insecticides

KW - Male

KW - Middle Aged

KW - Polychlorinated Biphenyls

KW - Prospective Studies

KW - Spain

KW - Young Adult

U2 - 10.1016/j.envres.2015.02.018

DO - 10.1016/j.envres.2015.02.018

M3 - Journal article

C2 - 25725302

SN - 0013-9351

VL - 138

SP - 217

EP - 223

JO - Environmental Research

JF - Environmental Research

ER -