@article{0a8c94c0d5d111dea1f3000ea68e967b,
title = "Histone methyltransferases in cancer",
abstract = "Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action.",
author = "Mareike Albert and Kristian Helin",
year = "2009",
month = apr,
doi = "10.1016/j.semcdb.2009.10.007",
language = "English",
volume = "21",
pages = "209--20",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press",
number = "2",
}
