Healthcare databases in Europe for studying medicine use and safety during pregnancy

Rachel A Charlton; Amanda J Neville; Sue Jordan; Anna Pierini; Christine Damase-Michel; Kari Klungsøyr; Anne-Marie Nybo Andersen; Anne Vinkel Hansen; Rosa Gini; Jens H J Bos; Aurora Puccini; Caroline Hurault-Delarue; Caroline J Brooks; Lolkje T W de Jong-van den Berg; Corinne S de Vries

doi:10.1002/pds.3613

Healthcare databases in Europe for studying medicine use and safety during pregnancy

Rachel A Charlton, Amanda J Neville, Sue Jordan, Anna Pierini, Christine Damase-Michel, Kari Klungsøyr, Anne-Marie Nybo Andersen, Anne Vinkel Hansen, Rosa Gini, Jens H J Bos, Aurora Puccini, Caroline Hurault-Delarue, Caroline J Brooks, Lolkje T W de Jong-van den Berg, Corinne S de Vries

https://www.ifsv.ku.dk/om-instituttet/socialmedicin/

39 Citationer (Scopus)

Abstract

Purpose: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. Methods: A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. Results: Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. Conclusion: This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest.

Originalsprog	Engelsk
Tidsskrift	Pharmacoepidemiology and Drug Safety
Vol/bind	23
Udgave nummer	6
Sider (fra-til)	586-94
Antal sider	9
ISSN	1053-8569
DOI	https://doi.org/10.1002/pds.3613
Status	Udgivet - jun. 2014

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10.1002/pds.3613

Citationsformater

Charlton, R. A., Neville, A. J., Jordan, S., Pierini, A., Damase-Michel, C., Klungsøyr, K., Andersen, A-M. N., Hansen, A. V., Gini, R., Bos, J. H. J., Puccini, A., Hurault-Delarue, C., Brooks, C. J., de Jong-van den Berg, L. T. W., & de Vries, C. S. (2014). Healthcare databases in Europe for studying medicine use and safety during pregnancy. Pharmacoepidemiology and Drug Safety, 23(6), 586-94. https://doi.org/10.1002/pds.3613

Charlton, RA, Neville, AJ, Jordan, S, Pierini, A, Damase-Michel, C, Klungsøyr, K, Andersen, A-MN, Hansen, AV, Gini, R, Bos, JHJ, Puccini, A, Hurault-Delarue, C, Brooks, CJ, de Jong-van den Berg, LTW & de Vries, CS 2014, 'Healthcare databases in Europe for studying medicine use and safety during pregnancy', Pharmacoepidemiology and Drug Safety, bind 23, nr. 6, s. 586-94. https://doi.org/10.1002/pds.3613

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title = "Healthcare databases in Europe for studying medicine use and safety during pregnancy",

abstract = "Purpose: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. Methods: A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. Results: Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. Conclusion: This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest.",

author = "Charlton, {Rachel A} and Neville, {Amanda J} and Sue Jordan and Anna Pierini and Christine Damase-Michel and Kari Klungs{\o}yr and Andersen, {Anne-Marie Nybo} and Hansen, {Anne Vinkel} and Rosa Gini and Bos, {Jens H J} and Aurora Puccini and Caroline Hurault-Delarue and Brooks, {Caroline J} and {de Jong-van den Berg}, {Lolkje T W} and {de Vries}, {Corinne S}",

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year = "2014",

month = jun,

doi = "10.1002/pds.3613",

language = "English",

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pages = "586--94",

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T1 - Healthcare databases in Europe for studying medicine use and safety during pregnancy

AU - Charlton, Rachel A

AU - Neville, Amanda J

AU - Jordan, Sue

AU - Pierini, Anna

AU - Damase-Michel, Christine

AU - Klungsøyr, Kari

AU - Andersen, Anne-Marie Nybo

AU - Hansen, Anne Vinkel

AU - Gini, Rosa

AU - Bos, Jens H J

AU - Puccini, Aurora

AU - Hurault-Delarue, Caroline

AU - Brooks, Caroline J

AU - de Jong-van den Berg, Lolkje T W

AU - de Vries, Corinne S

PY - 2014/6

Y1 - 2014/6

N2 - Purpose: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. Methods: A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. Results: Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. Conclusion: This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest.

AB - Purpose: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. Methods: A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. Results: Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. Conclusion: This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest.

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Healthcare databases in Europe for studying medicine use and safety during pregnancy

Abstract

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