Glucagon-like peptide-2 in umbilical cord blood from mature infants

Susan Bodé; Bolette Hartmann; Jens Juul Holst; Gorm Greisen

doi:10.1159/000096971

Glucagon-like peptide-2 in umbilical cord blood from mature infants

Susan Bodé, Bolette Hartmann, Jens Juul Holst, Gorm Greisen

2 Citationer (Scopus)

Abstract

BACKGROUND: Glucagon-like peptide-2 (GLP-2) seems to be a highly specific intestinotrophic mediator. From animal studies, GLP-2 is known to increase in the early neonatal period before it falls to adult level. No studies in newborn infants addressing this specific subject have been published so far.

OBJECTIVES: To measure GLP-2 concentrations in umbilical cord blood from healthy mature infants and to assess any influence from the processes associated with spontaneous birth to GLP-2 production.

SUBJECTS: Twenty-one children delivered by elective cesarean section for maternal reasons and 18 children delivered spontaneously vaginally and without complications were included. Gestational age (GA) was median (range) 38.7 (40.7-37.1) weeks and 40.2 (41.9-38) weeks, and birth weight was median (range) 3,210 (4,820-2,100) g and 3,396 (4,225-3,050) g, respectively. The infants had no diagnosed diseases or malformations.

METHODS: Umbilical cord blood was collected shortly after birth. Plasma was separated and GLP-2 immunoreactivity was measured with a specific NH(2)-terminal radioimmunoassay.

RESULTS: GLP-2 was detected in all samples. Mean values +/-SD were 16.7 +/- 3.9 pmol/l and range was 32-11 pmol/l, which is comparable to adult fasting levels. No significant correlation to birth weight (p = 0.087) or to cesarean section (p = 0.059) was found. In multiple linear regression analysis (GLP-2 vs. GA + cesarean section), neither vaginal delivery nor GA were statistically significantly related to the level of GLP-2 (p = 0.28 and 0.18), respectively.

CONCLUSIONS: GLP-2 is present in human cord blood by the time of birth. The level of GLP-2 is comparable to adult fasting levels. Spontaneous birth at most induces a minor increase in GLP-2 in term infants. In the narrow age interval studied, no significant effect of maturation was seen.

Originalsprog	Engelsk
Tidsskrift	Neonatology
Vol/bind	91
Udgave nummer	1
Sider (fra-til)	49-53
Antal sider	5
ISSN	1661-7800
DOI	https://doi.org/10.1159/000096971
Status	Udgivet - 2007

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@article{2d4a64680dc34925a2b3678c12b841ca,

title = "Glucagon-like peptide-2 in umbilical cord blood from mature infants",

abstract = "BACKGROUND: Glucagon-like peptide-2 (GLP-2) seems to be a highly specific intestinotrophic mediator. From animal studies, GLP-2 is known to increase in the early neonatal period before it falls to adult level. No studies in newborn infants addressing this specific subject have been published so far.OBJECTIVES: To measure GLP-2 concentrations in umbilical cord blood from healthy mature infants and to assess any influence from the processes associated with spontaneous birth to GLP-2 production.SUBJECTS: Twenty-one children delivered by elective cesarean section for maternal reasons and 18 children delivered spontaneously vaginally and without complications were included. Gestational age (GA) was median (range) 38.7 (40.7-37.1) weeks and 40.2 (41.9-38) weeks, and birth weight was median (range) 3,210 (4,820-2,100) g and 3,396 (4,225-3,050) g, respectively. The infants had no diagnosed diseases or malformations.METHODS: Umbilical cord blood was collected shortly after birth. Plasma was separated and GLP-2 immunoreactivity was measured with a specific NH(2)-terminal radioimmunoassay.RESULTS: GLP-2 was detected in all samples. Mean values +/-SD were 16.7 +/- 3.9 pmol/l and range was 32-11 pmol/l, which is comparable to adult fasting levels. No significant correlation to birth weight (p = 0.087) or to cesarean section (p = 0.059) was found. In multiple linear regression analysis (GLP-2 vs. GA + cesarean section), neither vaginal delivery nor GA were statistically significantly related to the level of GLP-2 (p = 0.28 and 0.18), respectively.CONCLUSIONS: GLP-2 is present in human cord blood by the time of birth. The level of GLP-2 is comparable to adult fasting levels. Spontaneous birth at most induces a minor increase in GLP-2 in term infants. In the narrow age interval studied, no significant effect of maturation was seen.",

keywords = "Birth Weight, Delivery, Obstetric, Female, Fetal Blood, Gestational Age, Glucagon-Like Peptide 2, Humans, Infant, Newborn, Male, Regression Analysis",

author = "Susan Bod{\'e} and Bolette Hartmann and Holst, {Jens Juul} and Gorm Greisen",

year = "2007",

doi = "10.1159/000096971",

language = "English",

volume = "91",

pages = "49--53",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S Karger AG",

number = "1",

}

TY - JOUR

T1 - Glucagon-like peptide-2 in umbilical cord blood from mature infants

AU - Bodé, Susan

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Greisen, Gorm

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Glucagon-like peptide-2 (GLP-2) seems to be a highly specific intestinotrophic mediator. From animal studies, GLP-2 is known to increase in the early neonatal period before it falls to adult level. No studies in newborn infants addressing this specific subject have been published so far.OBJECTIVES: To measure GLP-2 concentrations in umbilical cord blood from healthy mature infants and to assess any influence from the processes associated with spontaneous birth to GLP-2 production.SUBJECTS: Twenty-one children delivered by elective cesarean section for maternal reasons and 18 children delivered spontaneously vaginally and without complications were included. Gestational age (GA) was median (range) 38.7 (40.7-37.1) weeks and 40.2 (41.9-38) weeks, and birth weight was median (range) 3,210 (4,820-2,100) g and 3,396 (4,225-3,050) g, respectively. The infants had no diagnosed diseases or malformations.METHODS: Umbilical cord blood was collected shortly after birth. Plasma was separated and GLP-2 immunoreactivity was measured with a specific NH(2)-terminal radioimmunoassay.RESULTS: GLP-2 was detected in all samples. Mean values +/-SD were 16.7 +/- 3.9 pmol/l and range was 32-11 pmol/l, which is comparable to adult fasting levels. No significant correlation to birth weight (p = 0.087) or to cesarean section (p = 0.059) was found. In multiple linear regression analysis (GLP-2 vs. GA + cesarean section), neither vaginal delivery nor GA were statistically significantly related to the level of GLP-2 (p = 0.28 and 0.18), respectively.CONCLUSIONS: GLP-2 is present in human cord blood by the time of birth. The level of GLP-2 is comparable to adult fasting levels. Spontaneous birth at most induces a minor increase in GLP-2 in term infants. In the narrow age interval studied, no significant effect of maturation was seen.

AB - BACKGROUND: Glucagon-like peptide-2 (GLP-2) seems to be a highly specific intestinotrophic mediator. From animal studies, GLP-2 is known to increase in the early neonatal period before it falls to adult level. No studies in newborn infants addressing this specific subject have been published so far.OBJECTIVES: To measure GLP-2 concentrations in umbilical cord blood from healthy mature infants and to assess any influence from the processes associated with spontaneous birth to GLP-2 production.SUBJECTS: Twenty-one children delivered by elective cesarean section for maternal reasons and 18 children delivered spontaneously vaginally and without complications were included. Gestational age (GA) was median (range) 38.7 (40.7-37.1) weeks and 40.2 (41.9-38) weeks, and birth weight was median (range) 3,210 (4,820-2,100) g and 3,396 (4,225-3,050) g, respectively. The infants had no diagnosed diseases or malformations.METHODS: Umbilical cord blood was collected shortly after birth. Plasma was separated and GLP-2 immunoreactivity was measured with a specific NH(2)-terminal radioimmunoassay.RESULTS: GLP-2 was detected in all samples. Mean values +/-SD were 16.7 +/- 3.9 pmol/l and range was 32-11 pmol/l, which is comparable to adult fasting levels. No significant correlation to birth weight (p = 0.087) or to cesarean section (p = 0.059) was found. In multiple linear regression analysis (GLP-2 vs. GA + cesarean section), neither vaginal delivery nor GA were statistically significantly related to the level of GLP-2 (p = 0.28 and 0.18), respectively.CONCLUSIONS: GLP-2 is present in human cord blood by the time of birth. The level of GLP-2 is comparable to adult fasting levels. Spontaneous birth at most induces a minor increase in GLP-2 in term infants. In the narrow age interval studied, no significant effect of maturation was seen.

KW - Birth Weight

KW - Delivery, Obstetric

KW - Female

KW - Fetal Blood

KW - Gestational Age

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Infant, Newborn

KW - Male

KW - Regression Analysis

U2 - 10.1159/000096971

DO - 10.1159/000096971

M3 - Journal article

C2 - 17344652

SN - 1661-7800

VL - 91

SP - 49

EP - 53

JO - Neonatology

JF - Neonatology

IS - 1

ER -

Glucagon-like peptide-2 in umbilical cord blood from mature infants

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