Genetically Modified Mice in Medical and Pharmaceutical Research

Cord Brakebusch

doi:10.1002/9783527620982.ch27

Genetically Modified Mice in Medical and Pharmaceutical Research

^*Corresponding author af dette arbejde

Abstract

Genetically altered mice are important models to study the mechanism of inherited and acquired diseases. Furthermore, these mice are extremely useful to test the efficacy of new therapies and to validate potential drug targets. Although the generation of mice carrying point mutations or deletions of specific genes is quite well established, it is still a relatively long procedure. Careful planning of the gene targeting is therefore essential. In this chapter we describe the general procedure of generating genetically altered mice and discuss potential problems that could be encountered and their solution.

Originalsprog	Engelsk
Titel	Modern Biopharmaceuticals : Design, Development and Optimization
Antal sider	12
Vol/bind	2
Forlag	Wiley-VCH
Publikationsdato	5 feb. 2008
Sider	649-660
ISBN (Trykt)	352731184X, 9783527311842
DOI	https://doi.org/10.1002/9783527620982.ch27
Status	Udgivet - 5 feb. 2008

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Genetically Modified Mice in Medical and Pharmaceutical Research

Abstract

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