Functional consequences of integrin gene mutations in mice.

TY - JOUR

T1 - Functional consequences of integrin gene mutations in mice.

AU - Bouvard, D

AU - Brakebusch, C

AU - Gustafsson, E

AU - Aszódi, A

AU - Bengtsson, T

AU - Berna, A

AU - Fässler, R

N1 - Keywords: Animals; Cell Migration Inhibition; Embryonic and Fetal Development; Genes, Lethal; Hematopoiesis; Hemostasis; Integrins; Leukocytes; Ligands; Mice; Mice, Mutant Strains; Mutation; Neovascularization, Physiologic; Phenotype; Signal Transduction

PY - 2001

Y1 - 2001

N2 - Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.

AB - Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.

M3 - Journal article

C2 - 11485971

SN - 0009-7330

VL - 89

SP - 211

EP - 223

JO - Circulation Research

JF - Circulation Research

IS - 3

ER -