Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay

Medicin og biovidenskab

• Gluk2 kainate receptor 100%
• High-Throughput Screening Assays 80%
• HEK293 Cells 61%
• cyclothiazide 47%
• Fluorescence 46%
• Fluo 4 44%
• 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline 43%
• Quisqualic Acid 41%
• Ligands 40%
• Excitatory Amino Acid Agonists 39%
• Ionotropic Glutamate Receptors 38%
• Pharmacology 38%
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35%
• AMPA Receptors 33%
• Cell Line 33%
• Kainic Acid 33%
• Electrophysiology 32%
• Concanavalin A 31%
• Xenopus 30%
• Oocytes 26%
• Buffers 26%
• Libraries 25%

Teknik og materialevidenskab

• Assays 66%
• Fluorescence 65%
• Screening 52%
• Cells 41%
• Throughput 39%
• Ligands 37%
• Electrophysiology 21%
• Rats 16%
• Modulators 14%

Kemiske forbindelser

• High Throughput Screening 61%
• Cyclothiazide 54%
• Fluo-4 51%
• Pharmacological Property 33%
• Mammalian Cell 29%
• Agonist 27%
• Antagonist 26%
• Ligand 24%
• Indicator 24%
• Buffer Solution 18%