Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study

TY - JOUR

T1 - Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population

T2 - the Copenhagen City Heart Study

AU - Kamstrup, Pia R

AU - Benn, Marianne

AU - Tybjaerg-Hansen, Anne

AU - Nordestgaard, Børge G

PY - 2008

Y1 - 2008

N2 - Elevated lipoprotein(a) levels are associated with myocardial infarction (MI) in some but not all studies. Limitations of previous studies include lack of risk estimates for extreme lipoprotein(a) levels, measurements in long-term frozen samples, no correction for regression dilution bias, and lack of absolute risk estimates in the general population. We tested the hypothesis that extreme lipoprotein(a) levels predict MI in the general population, measuring levels shortly after sampling, correcting for regression dilution bias, and calculating hazard ratios and absolute risk estimates.

AB - Elevated lipoprotein(a) levels are associated with myocardial infarction (MI) in some but not all studies. Limitations of previous studies include lack of risk estimates for extreme lipoprotein(a) levels, measurements in long-term frozen samples, no correction for regression dilution bias, and lack of absolute risk estimates in the general population. We tested the hypothesis that extreme lipoprotein(a) levels predict MI in the general population, measuring levels shortly after sampling, correcting for regression dilution bias, and calculating hazard ratios and absolute risk estimates.

U2 - http://dx.doi.org/10.1161/CIRCULATIONAHA.107.715698

DO - http://dx.doi.org/10.1161/CIRCULATIONAHA.107.715698

M3 - Journal article

SN - 0009-7322

VL - 117

SP - 176

EP - 184

JO - Circulation

JF - Circulation

IS - 2

ER -