Exposures that may affect sperm DNA integrity: two decades of follow-up in a pregnancy cohort

TY - JOUR

T1 - Exposures that may affect sperm DNA integrity

T2 - two decades of follow-up in a pregnancy cohort

AU - Håkonsen, L B

AU - Spano, M

AU - Bonde, J P

AU - Olsen, J

AU - Thulstrup, A M

AU - Ernst, E

AU - Ramlau-Hansen, C H

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012/6

Y1 - 2012/6

N2 - Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984-1987, sons were selected for a follow-up study in 2005-2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: -3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: -4; 34) higher DFI than sons of parents with a TTP of 0-6 months. Abstinence time was positively associated with DFI (p

AB - Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984-1987, sons were selected for a follow-up study in 2005-2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: -3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: -4; 34) higher DFI than sons of parents with a TTP of 0-6 months. Abstinence time was positively associated with DFI (p

U2 - 10.1016/j.reprotox.2011.12.013

DO - 10.1016/j.reprotox.2011.12.013

M3 - Journal article

C2 - 22230645

SN - 0890-6238

VL - 33

SP - 316

EP - 321

JO - Reproductive Toxicology

JF - Reproductive Toxicology

IS - 3

ER -