Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

P. S. Christensen; J. P. Bonde; L. Bungum; A. Giwercman; G. Toft; B. A. G. Jönsson; I. O. Specht

doi:10.1016/j.reprotox.2016.03.047

Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

P. S. Christensen, J. P. Bonde, L. Bungum, A. Giwercman, G. Toft, B. A. G. Jönsson, I. O. Specht

Institut for Folkesundhedsvidenskab

6 Citationer (Scopus)

Abstract

BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.

MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.

RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).

CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.

Originalsprog	Engelsk
Tidsskrift	Reproductive Toxicology
Vol/bind	61
Sider (fra-til)	114-119
Antal sider	6
ISSN	0890-6238
DOI	https://doi.org/10.1016/j.reprotox.2016.03.047
Status	Udgivet - 1 jun. 2016

Adgang til dokumentet

10.1016/j.reprotox.2016.03.047

Citationsformater

@article{d0c45eeb64894b58915a9ef489de3ea8,

title = "Environmental cadmium and lead exposure and anti-M{\"u}llerian hormone in pregnant women",

abstract = "BACKGROUND: Anti-M{\"u}llerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.",

keywords = "Journal Article",

author = "Christensen, {P. S.} and Bonde, {J. P.} and L. Bungum and A. Giwercman and G. Toft and J{\"o}nsson, {B. A. G.} and Specht, {I. O.}",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.reprotox.2016.03.047",

language = "English",

volume = "61",

pages = "114--119",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier",

}

TY - JOUR

T1 - Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

AU - Christensen, P. S.

AU - Bonde, J. P.

AU - Bungum, L.

AU - Giwercman, A.

AU - Toft, G.

AU - Jönsson, B. A. G.

AU - Specht, I. O.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.

AB - BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.

KW - Journal Article

U2 - 10.1016/j.reprotox.2016.03.047

DO - 10.1016/j.reprotox.2016.03.047

M3 - Journal article

C2 - 27049579

SN - 0890-6238

VL - 61

SP - 114

EP - 119

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater