@article{214f0790acad11ddb5e9000ea68e967b,
title = "EBF2 regulates osteoblast-dependent differentiation of osteoclasts.",
abstract = "Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:beta-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.",
author = "Matthias Kieslinger and Stephanie Folberth and Gergana Dobreva and Tatjana Dorn and Laura Croci and Reinhold Erben and Consalez, {G Giacomo} and Rudolf Grosschedl",
note = "Keywords: Animals; Basic Helix-Loop-Helix Transcription Factors; Bone Development; Bone Resorption; Carrier Proteins; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation; Glycoproteins; Hela Cells; Homozygote; Humans; In Situ Hybridization; Lymphoid Enhancer-Binding Factor 1; Membrane Glycoproteins; Mice; Mice, Knockout; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Promoter Regions (Genetics); RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Signal Transduction; T Cell Transcription Factor 1; Trans-Activation (Genetics); Trans-Activators; Wnt Proteins; beta Catenin",
year = "2005",
doi = "10.1016/j.devcel.2005.10.009",
language = "English",
volume = "9",
pages = "757--67",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",
}