Early Life Events Predict Adult Testicular Function: Data Derived From the Western Australian (Raine) Birth Cohort

TY - JOUR

T1 - Early Life Events Predict Adult Testicular Function

T2 - Data Derived From the Western Australian (Raine) Birth Cohort

AU - Hart, Roger J

AU - Doherty, Dorota A

AU - Keelan, Jeffrey A

AU - McLachlan, Rob

AU - Skakkebæk, Niels Erik

AU - Norman, Robert J

AU - Dickinson, Jan E

AU - Pennell, Craig E

AU - Newnham, John P

AU - Hickey, Martha

AU - Handelsman, David J

PY - 2016/9

Y1 - 2016/9

N2 - Context: The impact of early life events on testicular function in adulthood is not well understood. Objective: To study the early influences of fetal growth, exposures to cigarette smoke in utero and cord blood estrogens, and the influences of growth and adiposity in childhood through adolescence; on testicular function in adulthood. Design: Male members of the Western Australian Pregnancy Cohort (Raine) were contacted at 20-22 years of age. Of 913 contacted, 423 (56%) agreed to participate; 404 underwent a testicular ultrasound, 365 provided a semen sample, and reproductive hormones were measured (384). Fetal growth measurements (n = 137), umbilical cord estrogen concentrations (n = 128), cord testosterone (T) (n = 125), and child-adulthood growth charts (n = 395) were available. Results: Median sperm output for the 18.6% of men exposed in utero to smoking was lower than nonexposed (82.4 × 106 vs 123.1 × 106; P = .029). Sperm output in adulthood was inversely correlated with cord serum estradiol (P = .019) and estrone (P = .018). The sperm output of men whose cord blood estradiol and estrone were less than 50th percentile vs more than 50th percentile was 191.1 × 106 vs 100.5 × 106 (P = .002) and 190.0 × 106 vs 106.0 × 106 (P = .012), respectively. Menwith favorable fetal growth patterns in uterowereless likely to have total motile sperm counts within the lowest quartile (P = .011), and men born prematurely had reduced serum T levels in adulthood (13.4 vs 16.6nmol/L, P = .024). Consistent height above the 50th percentile for age through childhood was associated with larger adult mean testicular volume (P > .001). Optimal body mass index trajectory through childhood and adolescence was associated with larger testicular volume (P = .009) and higher serum inhibin B (P = .010) and T (P = .003) in adulthood. Conclusions: Exposures to maternal smoking and higher cord blood estrogens at delivery were associated with a reduced sperm output in adulthood. Optimal adult testicular function depends on being born at or above average weight, and maintaining optimal growth and adiposity into adulthood.

AB - Context: The impact of early life events on testicular function in adulthood is not well understood. Objective: To study the early influences of fetal growth, exposures to cigarette smoke in utero and cord blood estrogens, and the influences of growth and adiposity in childhood through adolescence; on testicular function in adulthood. Design: Male members of the Western Australian Pregnancy Cohort (Raine) were contacted at 20-22 years of age. Of 913 contacted, 423 (56%) agreed to participate; 404 underwent a testicular ultrasound, 365 provided a semen sample, and reproductive hormones were measured (384). Fetal growth measurements (n = 137), umbilical cord estrogen concentrations (n = 128), cord testosterone (T) (n = 125), and child-adulthood growth charts (n = 395) were available. Results: Median sperm output for the 18.6% of men exposed in utero to smoking was lower than nonexposed (82.4 × 106 vs 123.1 × 106; P = .029). Sperm output in adulthood was inversely correlated with cord serum estradiol (P = .019) and estrone (P = .018). The sperm output of men whose cord blood estradiol and estrone were less than 50th percentile vs more than 50th percentile was 191.1 × 106 vs 100.5 × 106 (P = .002) and 190.0 × 106 vs 106.0 × 106 (P = .012), respectively. Menwith favorable fetal growth patterns in uterowereless likely to have total motile sperm counts within the lowest quartile (P = .011), and men born prematurely had reduced serum T levels in adulthood (13.4 vs 16.6nmol/L, P = .024). Consistent height above the 50th percentile for age through childhood was associated with larger adult mean testicular volume (P > .001). Optimal body mass index trajectory through childhood and adolescence was associated with larger testicular volume (P = .009) and higher serum inhibin B (P = .010) and T (P = .003) in adulthood. Conclusions: Exposures to maternal smoking and higher cord blood estrogens at delivery were associated with a reduced sperm output in adulthood. Optimal adult testicular function depends on being born at or above average weight, and maintaining optimal growth and adiposity into adulthood.

KW - Journal Article

U2 - 10.1210/jc.2016-1646

DO - 10.1210/jc.2016-1646

M3 - Journal article

C2 - 27340882

SN - 0021-972X

VL - 101

SP - 3333

EP - 3344

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 9

ER -