Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins

TY - JOUR

T1 - Early-life environment influencing susceptibility to cytomegalovirus infection

T2 - evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins

AU - Mortensen, Laust Hvas

AU - Maier, A B

AU - Slagbom, P E

AU - Pawelec, G

AU - Derhovanessian, E

AU - Petersen, I.

AU - Jahn, G

AU - Westendorp, R G J

AU - Christensen, K

PY - 2012/5

Y1 - 2012/5

N2 - Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42% vs. partners: 51%, P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90% vs. DZ: 88%, P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.

AB - Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42% vs. partners: 51%, P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90% vs. DZ: 88%, P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.

KW - Aged

KW - Aged, 80 and over

KW - Cytomegalovirus Infections

KW - Denmark

KW - Disease Susceptibility

KW - Female

KW - Humans

KW - Longevity

KW - Longitudinal Studies

KW - Male

KW - Netherlands

KW - Seroepidemiologic Studies

KW - Survival Analysis

KW - Twins

U2 - 10.1017/s0950268811001397

DO - 10.1017/s0950268811001397

M3 - Journal article

C2 - 21781370

SN - 0950-2688

VL - 140

SP - 835

EP - 841

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 5

ER -