TY - JOUR
T1 - Does last week's alcohol intake affect semen quality or reproductive hormones?
T2 - A cross-sectional study among healthy young Danish men
AU - Hansen, M L
AU - Thulstrup, A M
AU - Bonde, J P
AU - Olsen, J
AU - Håkonsen, L B
AU - Ramlau-Hansen, C H
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012/11
Y1 - 2012/11
N2 - The association between last 5 days of alcohol intake, semen quality and reproductive hormones was estimated in this cross-sectional study among 347 men. Conventional semen characteristics, DNA fragmentation index and reproductive hormones (testosterone, estradiol, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and inhibin B) were determined. There was a tendency towards lower semen characteristics at higher intake of alcohol past 5 days, albeit with no statistically significant dose-response association. The ratio between free estradiol and free testosterone was higher at higher alcohol intake during the 5 days preceding semen sampling. In conclusion, alcohol intake was associated with impairment of most semen characteristics but without a coherent dose-response pattern. The study indicates an association between recent alcohol intake and a hormonal shift towards higher estradiol/testosterone ratio. The hormonal changes observed may over time, lead to adverse effects on semen quality, but longitudinal studies are needed to study this.
AB - The association between last 5 days of alcohol intake, semen quality and reproductive hormones was estimated in this cross-sectional study among 347 men. Conventional semen characteristics, DNA fragmentation index and reproductive hormones (testosterone, estradiol, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and inhibin B) were determined. There was a tendency towards lower semen characteristics at higher intake of alcohol past 5 days, albeit with no statistically significant dose-response association. The ratio between free estradiol and free testosterone was higher at higher alcohol intake during the 5 days preceding semen sampling. In conclusion, alcohol intake was associated with impairment of most semen characteristics but without a coherent dose-response pattern. The study indicates an association between recent alcohol intake and a hormonal shift towards higher estradiol/testosterone ratio. The hormonal changes observed may over time, lead to adverse effects on semen quality, but longitudinal studies are needed to study this.
U2 - 10.1016/j.reprotox.2012.06.004
DO - 10.1016/j.reprotox.2012.06.004
M3 - Journal article
C2 - 22732148
SN - 0890-6238
VL - 34
SP - 457
EP - 462
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 3
ER -