Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine

Julie A McMurry; Stephen H Gregory; Leonard Moise; Daniel Rivera; Soren Buus; Anne S De Groot

doi:10.1016/j.vaccine.2007.01.039

Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine

Julie A McMurry, Stephen H Gregory, Leonard Moise, Daniel Rivera, Soren Buus, Anne S De Groot

LUKKET: Institut for Immunologi og Mikrobiologi

58 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Apr-20

Originalsprog	Engelsk
Tidsskrift	Vaccine
Vol/bind	25
Udgave nummer	16
Sider (fra-til)	3179-91
Antal sider	12
ISSN	0264-410X
DOI	https://doi.org/10.1016/j.vaccine.2007.01.039
Status	Udgivet - 2007

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10.1016/j.vaccine.2007.01.039

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Citationsformater

McMurry, J. A., Gregory, S. H., Moise, L., Rivera, D., Buus, S., & De Groot, A. S. (2007). Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine. Vaccine, 25(16), 3179-91. https://doi.org/10.1016/j.vaccine.2007.01.039

Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine. / McMurry, Julie A; Gregory, Stephen H; Moise, Leonard et al.

I: Vaccine, Bind 25, Nr. 16, 2007, s. 3179-91.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

McMurry, JA, Gregory, SH, Moise, L, Rivera, D, Buus, S & De Groot, AS 2007, 'Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine', Vaccine, bind 25, nr. 16, s. 3179-91. https://doi.org/10.1016/j.vaccine.2007.01.039

@article{40247d70ebc911ddbf70000ea68e967b,

title = "Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine",

abstract = "The T lymphocyte antigens, which may have a role in protection against tularemia, were predicted by immunoinformatics analysis of Francisella tularensis Schu4. Twenty-seven class II putative promiscuous epitopes and 125 putative class I supertype epitopes were chosen for synthesis; peptides were tested in vitro for their ability to bind HLA and to induce immune responses from PBMCs of 23 previously infected subjects. While the immune responses of individual subjects showed heterogeneity, 95% of the subjects responded strongly to a pool of 27 promiscuous peptides; 25%, 33%, and 44% of subjects responded to pools of 25 A2, A24, and B7 peptides, respectively. These data can aid in the development of novel epitope-based and subunit tularemia vaccines.",

author = "McMurry, {Julie A} and Gregory, {Stephen H} and Leonard Moise and Daniel Rivera and Soren Buus and {De Groot}, {Anne S}",

note = "Keywords: Adult; Aged; Aged, 80 and over; Antigens, Bacterial; Bacterial Vaccines; Drug Design; Epitopes; Female; Francisella tularensis; Genes, MHC Class II; Humans; Male; Middle Aged; T-Lymphocytes; Tularemia; Vaccination",

year = "2007",

doi = "10.1016/j.vaccine.2007.01.039",

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T1 - Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine

AU - McMurry, Julie A

AU - Gregory, Stephen H

AU - Moise, Leonard

AU - Rivera, Daniel

AU - Buus, Soren

AU - De Groot, Anne S

N1 - Keywords: Adult; Aged; Aged, 80 and over; Antigens, Bacterial; Bacterial Vaccines; Drug Design; Epitopes; Female; Francisella tularensis; Genes, MHC Class II; Humans; Male; Middle Aged; T-Lymphocytes; Tularemia; Vaccination

PY - 2007

Y1 - 2007

N2 - The T lymphocyte antigens, which may have a role in protection against tularemia, were predicted by immunoinformatics analysis of Francisella tularensis Schu4. Twenty-seven class II putative promiscuous epitopes and 125 putative class I supertype epitopes were chosen for synthesis; peptides were tested in vitro for their ability to bind HLA and to induce immune responses from PBMCs of 23 previously infected subjects. While the immune responses of individual subjects showed heterogeneity, 95% of the subjects responded strongly to a pool of 27 promiscuous peptides; 25%, 33%, and 44% of subjects responded to pools of 25 A2, A24, and B7 peptides, respectively. These data can aid in the development of novel epitope-based and subunit tularemia vaccines.

AB - The T lymphocyte antigens, which may have a role in protection against tularemia, were predicted by immunoinformatics analysis of Francisella tularensis Schu4. Twenty-seven class II putative promiscuous epitopes and 125 putative class I supertype epitopes were chosen for synthesis; peptides were tested in vitro for their ability to bind HLA and to induce immune responses from PBMCs of 23 previously infected subjects. While the immune responses of individual subjects showed heterogeneity, 95% of the subjects responded strongly to a pool of 27 promiscuous peptides; 25%, 33%, and 44% of subjects responded to pools of 25 A2, A24, and B7 peptides, respectively. These data can aid in the development of novel epitope-based and subunit tularemia vaccines.

U2 - 10.1016/j.vaccine.2007.01.039

DO - 10.1016/j.vaccine.2007.01.039

M3 - Journal article

C2 - 17291638

SN - 0264-410X

VL - 25

SP - 3179

EP - 3191

JO - Vaccine

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