Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

Roberto Pérez-Torrado; Silvia Llopis; Lene Jespersen; Teresa Fernández-Espinar; Amparo Querol

doi:10.1016/j.ijfoodmicro.2012.04.012

Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

Roberto Pérez-Torrado, Silvia Llopis, Lene Jespersen, Teresa Fernández-Espinar, Amparo Querol

14 Citationer (Scopus)

Abstract

Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelialbarrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelialbarrier integrity is previously compromised.

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Originalsprog	Engelsk
Tidsskrift	International Journal of Food Microbiology
Vol/bind	157
Udgave nummer	1
Sider (fra-til)	59-64
Antal sider	6
ISSN	0168-1605
DOI	https://doi.org/10.1016/j.ijfoodmicro.2012.04.012
Status	Udgivet - 15 jun. 2012

Adgang til dokumentet

10.1016/j.ijfoodmicro.2012.04.012

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Citationsformater

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AU - Pérez-Torrado, Roberto

AU - Llopis, Silvia

AU - Jespersen, Lene

AU - Fernández-Espinar, Teresa

AU - Querol, Amparo

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