Changes in the repertoire of natural antibodies caused by immunization with bacterial antigens

TY - JOUR

T1 - Changes in the repertoire of natural antibodies caused by immunization with bacterial antigens

AU - Shilova, N V

AU - Navakouski, M J

AU - Huflejt, M

AU - Kuehn, A

AU - Grunow, R

AU - Blixt, Klas Ola

AU - Bovin, N V

PY - 2011/7

Y1 - 2011/7

N2 - The repertoire of natural anti-glycan antibodies in naive chickens and in chickens immunized with bacteria Burkholderia mallei, Burkholderia pseudomallei, and Francisella tularensis as well as with peptides from an outer membrane protein of B. pseudomallei was studied. A relatively restricted pattern of natural antibodies (first of all IgY against bacterial cell wall peptidoglycan fragments, L-Rha, and core N-acetyllactosamine) shrank and, moreover, the level of detectable antibodies decreased as a result of immunization.

AB - The repertoire of natural anti-glycan antibodies in naive chickens and in chickens immunized with bacteria Burkholderia mallei, Burkholderia pseudomallei, and Francisella tularensis as well as with peptides from an outer membrane protein of B. pseudomallei was studied. A relatively restricted pattern of natural antibodies (first of all IgY against bacterial cell wall peptidoglycan fragments, L-Rha, and core N-acetyllactosamine) shrank and, moreover, the level of detectable antibodies decreased as a result of immunization.

KW - Animals

KW - Antigens, Bacterial

KW - Bacterial Outer Membrane Proteins

KW - Burkholderia mallei

KW - Burkholderia pseudomallei

KW - Carbohydrate Sequence

KW - Chickens

KW - Francisella tularensis

KW - Immunity, Innate

KW - Immunization

KW - Immunoglobulins

KW - Molecular Sequence Data

U2 - 10.1134/s0006297911070170

DO - 10.1134/s0006297911070170

M3 - Journal article

C2 - 21999548

SN - 0006-2979

VL - 76

SP - 862

EP - 866

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

IS - 7

ER -