Carrier frequency of a nonsense mutation in the adenosine deaminase (ADA) gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common haplotype indicates common ancestry

Medicin og biovidenskab

• Somalia 100%
• Severe combined immunodeficiency due to adenosine deaminase deficiency 99%
• Adenosine Deaminase 79%
• Nonsense Codon 72%
• Haplotypes 59%
• Incidence 30%
• Genes 25%
• Severe Combined Immunodeficiency 16%
• Likelihood Functions 6%
• Alu Elements 6%
• Transcription Initiation Site 4%
• Mutation 4%
• Denmark 4%
• Missense Mutation 4%
• Parents 3%
• Alleles 3%
• Child 1%