Abstract
Obesity increases the risk of type 2 diabetes, cardiovascular diseases, and certain cancers, which are among the leading causes of death worldwide. Obesity and obesity-related metabolic diseases are characterized by specific alterations in the human gut microbiota. Experimental studies with gut microbiota transplantations in mice and in humans indicate that a specific gut microbiota composition can be the cause and not just the consequence of the obese state and metabolic disease, which suggests a potential for gut microbiota modulation in prevention and treatment of obesity-related metabolic diseases. In addition, dietary intervention studies have suggested that modulation of the gut microbiota can improve metabolic risk markers in humans, but a causal role of the gut microbiota in such studies has not yet been established. Here, we review and discuss the role of the gut microbiota in obesity-related metabolic diseases and the potential of dietary modulation of the gut microbiota in metabolic disease prevention and treatment.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Advances in Nutrition |
| Vol/bind | 7 |
| Udgave nummer | 1 |
| Sider (fra-til) | 90-101 |
| Antal sider | 12 |
| ISSN | 2161-8313 |
| DOI | |
| Status | Udgivet - 2016 |
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